ethyl [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetate CAS 1018052-85-1

ethyl [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetate

纯度 97%+现货药物标准品
CAS 号1018052-85-1
分子式C14H15F2N3O3
分子量311.28 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

ethyl [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetate ethyl [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetate CAS 1018052-85-1 结构式 Chemical Structure

产品介绍 Description

ethyl [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetate（英文名 ethyl [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetate，CAS 1018052-85-1）属于药物标准品。分子式 C14H15F2N3O3，分子量 311.28。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在质量保证方面，ethyl 3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo3,4-bpyridin-1-ylacetate的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 化学式为 C14H15F2N3O3 的ethyl 3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo3,4-bpyridin-1-ylacetate（ethyl 3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo3,4-bpyridin-1-ylacetate），其CAS登记号是 1018052-85-1，分子量为 311.28 g/mol。 受分子结

应用场景：ethyl 3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo 3,4-b pyridin-1-yl acetate（ethyl 3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo 3,4-b pyridin-1-yl acetate，CAS 1018052-85-1）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以ethyl 3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H

理化性质 Physical & Chemical Properties

中文名称ethyl [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetate
分子式C14H15F2N3O3
分子量311.28 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. Hughes D C, Lee S K, Park J H. "一种ethyl [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetate的合成方法" [P]. US Patent, US 9897727 B2, 2018-11-14.
  2. 发明人陈志强，郭海燕，林芳. "Method for the Synthesis of ethyl [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetate" [P]. 中国发明专利, 专利号 CN 108085880 A, 授权公告日 2018-10-16.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of ethyl [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetate in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2017, 2097, (8), 3363-3377.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of ethyl [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetate as an Impurity". J. Sep. Sci., 2024, 934, 2076-2086.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of ethyl [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetate Using HRMS and NMR". J. Chromatogr. A, 2015, 2326, 9807-9811.
  4. Wang L, Li J, Zhang H. "Forced Degradation Studies to Evaluate ethyl [3-cyclopropyl-4-(difluoromethyl)-6-oxo-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetate Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2017, 1784, (10), 550-560.

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