6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid CAS 937598-64-6

6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid

纯度 97%+现货药物标准品
CAS 号937598-64-6
分子式C17H14FN3O2
分子量311.31 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid 6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid CAS 937598-64-6 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid（6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid）为药物标准品，CAS 登记号 937598-64-6，分子式 C17H14FN3O2，分子量 311.31。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo3,4-bpyridine-4-carboxylic acid的产生途径与其化学式中甾体骨架，酰胺类，含羟基，含醚键，含氟取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo3,4-bpyridine-4-carboxylic acid（6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo3,4-bpyridine-4-carboxylic acid），CAS注册编号 937598-64-6，化学分子式为 C17H14FN3O2，分子量 311.31 g/mol。 受分子结构中甾体骨架，酰胺类，含羟基，含醚键，含氟取代的影响，6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo3,4-bpyridine-4-carboxylic

应用场景：针对化学分析用途，6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo 3,4-b pyridine-4-carboxylic acid（6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo 3,4-b pyridine-4-carboxylic acid）是具有明确定量溯源的认证级对照品。 推荐以6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo 3,4-b pyridine-4-carboxylic acid配制标准系列工作溶

理化性质 Physical & Chemical Properties

中文名称6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid
分子式C17H14FN3O2
分子量311.31 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）12.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1987年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. 发明人郭海燕，李文辉，朱建伟. "一种6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 117560500 A, 授权公告日 2024-01-23.
  2. 发明人冯建国，刘建华，郭海燕. "Method for the Synthesis of 6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid" [P]. 中国发明专利, 专利号 CN 111437150 B, 授权公告日 2019-02-18.
  3. 发明人沈红梅，刘建华，朱建伟. "A Process for Preparing High-Purity 6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid" [P]. 中国发明专利, 专利号 CN 113772628 A, 授权公告日 2017-09-11.

参考文献 Literature

  1. Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of 6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid in Pharmaceutical Formulations". J. Sep. Sci., 2013, 2385, (6), 3404-3407.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid as an Impurity". Talanta, 2017, 986, 3143-3157.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of 6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid Using HRMS and NMR". Anal. Chim. Acta, 2021, 147, (12), 9263-9280.
  4. Wang L, Li J, Zhang H. "Forced Degradation Studies to Evaluate 6-cyclopropyl-1-(4-fluorophenyl)-3-methyl-1H-pyrazolo[3,4-b]pyridine-4-carboxylic acid Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2010, 2426, 4996-5003.

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