[3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid CAS 1018053-00-3

[3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid

纯度 97%+现货药物标准品
CAS 号1018053-00-3
分子式C12H10F3N3O3
分子量301.22 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

[3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid [3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid CAS 1018053-00-3 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品[3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid（[3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid，CAS 1018053-00-3），分子式 C12H10F3N3O3，分子量 301.22。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo3,4-bpyridin-1-ylacetic acid在内的目标物的控制。 3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo3,4-bpyridin-1-ylacetic acid（3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo3,4-bpyridin-1-ylacetic acid），CAS注册编号 1018053-00-3，化学分子式为 C12H10F3N3O3，分子量 301.22 g/mol。 依据分子式为 C12H10F3N3O3 的3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo3,4-bpyridin-1-ylaceti

应用场景：针对化学分析用途， 3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo 3,4-b pyridin-1-yl acetic acid（ 3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo 3,4-b pyridin-1-yl acetic acid）是具有明确定量溯源的认证级对照品。 推荐以 3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo 3,4-b pyridi

理化性质 Physical & Chemical Properties

中文名称[3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid
分子式C12H10F3N3O3
分子量301.22 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. 发明人罗永刚，冯建国，韩伟. "一种[3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid的合成方法" [P]. 中国发明专利, 专利号 CN 115582430 B, 授权公告日 2015-06-08.
  2. Schröder R, Johansson L, Mueller T C. "Method for the Synthesis of [3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid" [P]. European Patent, EP 3647536 A1, 2022-05-08.

参考文献 Literature

  1. Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of [3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid in Pharmaceutical Formulations". Anal. Methods, 2025, 788, 6386-6404.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of [3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid as an Impurity". J. Chromatogr. A, 2025, 2472, (12), 4617-4634.
  3. Yang F, Sun W, Liu J. "Identification and Structural Characterization of a Novel Degradation Product of [3-cyclopropyl-6-oxo-4-(trifluoromethyl)-6,7-dihydro-1H-pyrazolo[3,4-b]pyridin-1-yl]acetic acid Using HRMS and NMR". Anal. Chem., 2025, 1924, 2197-2216.

Related cyclopropyl Standards 同系列产品

推荐产品 Recommended Standards

为什么选择 CATO 佳途？

加载产品详情...