3-[4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid CAS 1018126-77-6

3-[4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid

纯度 97%+现货药物标准品
CAS 号1018126-77-6
分子式C12H13F2N3O3
分子量285.25 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-[4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid 3-[4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid CAS 1018126-77-6 结构式 Chemical Structure

产品介绍 Description

3-[4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid（3-[4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid）是药物分析与质量控制领域常用的药物标准品，CAS 号 1018126-77-6。分子式 C12H13F2N3O3，分子量 285.25。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

化学式为 C12H13F2N3O3 的3-4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo3,4-bpyridin-7-ylpropanoic acid（3-4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo3,4-bpyridin-7-ylpropanoic acid），其CAS登记号是 1018126-77-6，分子量为 285.25 g/mol。 从化学结构特征来看，3-4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo3,4-bpyridin-7-ylpropanoic acid的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代。该化合物的不饱和度为7.0，表明结构中存在约7个环或双键等价单元。分子量为285.25 g/mol，属于中等分子量化合物。因分子内存在卤素取代基（F/Cl/Br/I），该化合物在质谱分析中呈现特征性的

应用场景：3- 4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo 3,4-b pyridin-7-yl propanoic acid（3- 4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo 3,4-b pyridin-7-yl propanoic acid）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以3- 4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo 3,4-b

理化性质 Physical & Chemical Properties

中文名称3-[4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid
分子式C12H13F2N3O3
分子量285.25 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. 发明人钱学锋，王建平，何建平. "一种3-[4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid的合成方法" [P]. 中国发明专利, 专利号 CN 110915941 A, 授权公告日 2015-04-21.
  2. 发明人沈红梅，徐明华，林芳. "Method for the Synthesis of 3-[4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid" [P]. 中国发明专利, 专利号 CN 113628896 B, 授权公告日 2022-07-15.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of 3-[4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid in Pharmaceutical Formulations". Anal. Chim. Acta, 2016, 1054, 936-951.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-[4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid as an Impurity". Chemosphere, 2021, 1434, (7), 9706-9711.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 3-[4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid Using HRMS and NMR". J. Chromatogr. A, 2019, 2061, (12), 2038-2057.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate 3-[4-(difluoromethyl)-2,3-dimethyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2013, 1764, (7), 7341-7365.

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