3-[4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid CAS 1018164-30-1

3-[4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid

纯度 97%+现货药物标准品
CAS 号1018164-30-1
分子式C14H17F2N3O3
分子量313.30 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-[4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid 3-[4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid CAS 1018164-30-1 结构式 Chemical Structure

产品介绍 Description

3-[4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid（3-[4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid）是药物分析与质量控制领域常用的药物标准品，CAS 号 1018164-30-1。分子式 C14H17F2N3O3，分子量 313.30。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

3-4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo3,4-bpyridin-7-ylpropanoic acid（C14H17F2N3O3）含有含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代。具有较强的吸湿性，卤素取代增加了化合物的密度和沸点，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。因分子内存在卤素取代基（F/Cl/Br/I），该化合物在质谱分析中呈现特征性的同位素分布模式，可作为定性确认的重要依据。 CAS编号 1018164-30-1 对应的化合物3-4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo3,4-bpyridin-7-ylpropanoic acid（英文标识 3-4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo3,4-bpyridi

应用场景：针对化学分析用途，3- 4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo 3,4-b pyridin-7-yl propanoic acid（3- 4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo 3,4-b pyridin-7-yl propanoic acid）是具有明确定量溯源的认证级对照品。 推荐以3- 4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-di

理化性质 Physical & Chemical Properties

中文名称3-[4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid
分子式C14H17F2N3O3
分子量313.30 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. 发明人韩伟，林芳，钱学锋. "一种3-[4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid的合成方法" [P]. 中国发明专利, 专利号 CN 110629722 B, 授权公告日 2025-11-07.
  2. 发明人钱学锋，周伟，韩伟. "Method for the Synthesis of 3-[4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid" [P]. 中国发明专利, 专利号 CN 116169684 A, 授权公告日 2022-02-17.
  3. 发明人陈志强，赵玉洁，徐明华. "A Process for Preparing High-Purity 3-[4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid" [P]. 中国发明专利, 专利号 CN 108389871 B, 授权公告日 2023-05-23.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of 3-[4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid in Pharmaceutical Formulations". Environ. Sci. Technol., 2012, 2111, (3), 821-836.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-[4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid as an Impurity". J. Sep. Sci., 2016, 1734, (1), 6406-6426.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 3-[4-(difluoromethyl)-2-isopropyl-3-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid Using HRMS and NMR". Chemosphere, 2024, 298, 7488-7509.

Related difluoromethyl Standards 同系列产品

推荐产品 Recommended Standards

为什么选择 CATO 佳途？

加载产品详情...