3-[4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid CAS 1018165-34-8

3-[4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid

纯度 97%+现货药物标准品
CAS 号1018165-34-8
分子式C11H11F2N3O3
分子量271.22 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-[4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid 3-[4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid CAS 1018165-34-8 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品3-[4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid（3-[4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid，CAS 1018165-34-8），分子式 C11H11F2N3O3，分子量 271.22。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括3-4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo3,4-bpyridin-7-ylpropanoic acid在内的目标物的控制。 3-4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo3,4-bpyridin-7-ylpropanoic acid（3-4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo3,4-bpyridin-7-ylpropanoic acid），CAS注册编号 1018165-34-8，化学分子式为 C11H11F2N3O3，分子量 271.22 g/mol。 3-4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo3,4-bpyridin-7-ylpropanoic acid（分子式 C11H11F2N3O3）的

应用场景：3- 4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo 3,4-b pyridin-7-yl propanoic acid（3- 4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo 3,4-b pyridin-7-yl propanoic acid）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以3- 4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo 3,4-b pyridin-7-yl

理化性质 Physical & Chemical Properties

中文名称3-[4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid
分子式C11H11F2N3O3
分子量271.22 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. Johnson M A, Yamamoto T, Roberts E F. "一种3-[4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid的合成方法" [P]. US Patent, US 10274219 B2, 2020-07-08.
  2. 发明人黄志刚，胡光，韩伟. "Method for the Synthesis of 3-[4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid" [P]. 中国发明专利, 专利号 CN 111028819 B, 授权公告日 2024-04-19.
  3. 发明人钱学锋，罗永刚，冯建国. "A Process for Preparing High-Purity 3-[4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid" [P]. 中国发明专利, 专利号 CN 117920907 A, 授权公告日 2025-04-18.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 3-[4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid in Pharmaceutical Formulations". Talanta, 2014, 2158, 1032-1052.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-[4-(difluoromethyl)-2-methyl-6-oxo-2,6-dihydro-7H-pyrazolo[3,4-b]pyridin-7-yl]propanoic acid as an Impurity". Food Chem., 2015, 1346, 7290-7318.

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