5-chloro-6-[(5-fluoro-2-methylphenyl)amino]pyridine-3-carboxylic acid CAS 1040006-05-0

5-chloro-6-[(5-fluoro-2-methylphenyl)amino]pyridine-3-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1040006-05-0
分子式C13H10ClFN2O2
分子量280.68 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-chloro-6-[(5-fluoro-2-methylphenyl)amino]pyridine-3-carboxylic acid 5-chloro-6-[(5-fluoro-2-methylphenyl)amino]pyridine-3-carboxylic acid CAS 1040006-05-0 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的5-chloro-6-[(5-fluoro-2-methylphenyl)amino]pyridine-3-carboxylic acid（5-chloro-6-[(5-fluoro-2-methylphenyl)amino]pyridine-3-carboxylic acid）为药物标准品，CAS 登记号 1040006-05-0，分子式 C13H10ClFN2O2，分子量 280.68。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括5-chloro-6-(5-fluoro-2-methylphenyl)aminopyridine-3-carboxylic acid在内的目标物的控制。 5-chloro-6-(5-fluoro-2-methylphenyl)aminopyridine-3-carboxylic acid（5-chloro-6-(5-fluoro-2-methylphenyl)aminopyridine-3-carboxylic acid），CAS注册编号 1040006-05-0，化学分子式为 C13H10ClFN2O2，分子量 280.68 g/mol。 从化学结构特征来看，5-chloro-6-(5-fluoro-2-methylphenyl)aminopyridine-3-carboxylic acid的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键，含氟/氯取代。该化合物的不饱和度为9.0，表明结构中存在约9个环或双键等价单元。分子量为280.68 g/mol，属于中等分子量化合物。分子中包含芳环或共轭体系，

应用场景：针对化学分析用途，5-chloro-6- (5-fluoro-2-methylphenyl)amino pyridine-3-carboxylic acid（5-chloro-6- (5-fluoro-2-methylphenyl)amino pyridine-3-carboxylic acid）是具有明确定量溯源的认证级对照品。 推荐以5-chloro-6- (5-fluoro-2-methylphenyl)amino pyridine-3-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需

理化性质 Physical & Chemical Properties

中文名称5-chloro-6-[(5-fluoro-2-methylphenyl)amino]pyridine-3-carboxylic acid
分子式C13H10ClFN2O2
分子量280.68 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
卤素含量F/Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人徐明华，唐晓军，王建平. "一种5-chloro-6-[(5-fluoro-2-methylphenyl)amino]pyridine-3-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 116812580 A, 授权公告日 2025-04-25.
  2. Anderson J P, Stevens L M, Roberts E F. "Method for the Synthesis of 5-chloro-6-[(5-fluoro-2-methylphenyl)amino]pyridine-3-carboxylic acid" [P]. US Patent, US 9590083 B2, 2020-11-08.
  3. Patel M V, Williams B T, Schröder R. "A Process for Preparing High-Purity 5-chloro-6-[(5-fluoro-2-methylphenyl)amino]pyridine-3-carboxylic acid" [P]. US Patent, US 11116247 B2, 2015-12-24.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of 5-chloro-6-[(5-fluoro-2-methylphenyl)amino]pyridine-3-carboxylic acid in Pharmaceutical Formulations". Anal. Chim. Acta, 2020, 696, (12), 1903-1923.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-chloro-6-[(5-fluoro-2-methylphenyl)amino]pyridine-3-carboxylic acid as an Impurity". Rapid Commun. Mass Spectrom., 2019, 1158, (2), 8167-8197.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 5-chloro-6-[(5-fluoro-2-methylphenyl)amino]pyridine-3-carboxylic acid Using HRMS and NMR". Molecules, 2024, 429, 3193-3199.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate 5-chloro-6-[(5-fluoro-2-methylphenyl)amino]pyridine-3-carboxylic acid Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2020, 1958, (10), 962-990.

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