1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid CAS 1049873-16-6

1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1049873-16-6
分子式C11H11N3O3
分子量233.22 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid 1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid CAS 1049873-16-6 结构式 Chemical Structure

产品介绍 Description

1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid（1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid，CAS 号 1049873-16-6）是 CATO 佳途自主生产的药物标准品，分子式 C11H11N3O3，分子量 233.22。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid的分子量为233.22 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid（1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid），CAS注册编号 1049873-16-6，化学分子式为 C11H11N3O3，分子量 233.22 g/mol。 1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid（C11H11N3O3）含有氨基酸衍生物，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳

应用场景：1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid（1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid，CAS 1049873-16-6）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法

理化性质 Physical & Chemical Properties

中文名称1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid
分子式C11H11N3O3
分子量233.22 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）8.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
含氮原子数3

相关专利 Related Patents

  1. 发明人徐明华，刘建华，郭海燕. "一种1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 110307878 A, 授权公告日 2025-12-04.
  2. Yamamoto T, Lee S K, Davis P L. "Method for the Synthesis of 1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid" [P]. US Patent, US 9380386 B2, 2022-10-02.
  3. 发明人陈志强，林芳，张德明. "A Process for Preparing High-Purity 1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 110218461 A, 授权公告日 2017-05-11.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid in Pharmaceutical Formulations". Phytochemistry, 2019, 2326, (9), 6223-6229.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid as an Impurity". Anal. Chem., 2015, 1164, 6204-6223.
  3. Martinez C, Lopez D R. "Identification and Structural Characterization of a Novel Degradation Product of 1-(4-methylphenyl)-6-oxo-1,4,5,6-tetrahydro-1,2,4-triazine-3-carboxylic acid Using HRMS and NMR". J. Agric. Food Chem., 2019, 1599, 7024-7051.

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