[(2,3-dimethoxyphenyl)methyl][2-(morpholin-4-yl)ethyl]amine dihydrochloride CAS 1050418-99-9

[(2,3-dimethoxyphenyl)methyl][2-(morpholin-4-yl)ethyl]amine dihydrochloride

纯度 97%+现货药物标准品
CAS 号1050418-99-9
分子式C15H24N2O3 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

[(2,3-dimethoxyphenyl)methyl][2-(morpholin-4-yl)ethyl]amine dihydrochloride [(2,3-dimethoxyphenyl)methyl][2-(morpholin-4-yl)ethyl]amine dihydrochloride CAS 1050418-99-9 结构式 Chemical Structure

产品介绍 Description

CAS 1050418-99-9 对应的[(2,3-dimethoxyphenyl)methyl][2-(morpholin-4-yl)ethyl]amine dihydrochloride（[(2,3-dimethoxyphenyl)methyl][2-(morpholin-4-yl)ethyl]amine dihydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C15H24N2O3 2*HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

作为认证标准物质（CRM），(2,3-dimethoxyphenyl)methyl2-(morpholin-4-yl)ethylamine dihydrochloride满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 化学式为 C15H24N2O3 2HCl 的(2,3-dimethoxyphenyl)methyl2-(morpholin-4-yl)ethylamine dihydrochloride（(2,3-dimethoxyphenyl)methyl2-(morpholin-4-yl)ethylamine dihydrochloride），其CAS登记号是 1050418-99-9，分子量为 316.83 g/mol。 从化学结构特征来看，(2,3-dimethoxyphenyl)methyl2-(morpholin-4-yl)ethylamine dihydrochloride的分子骨架中包含含氮杂环

应用场景：针对化学分析用途， (2,3-dimethoxyphenyl)methyl 2-(morpholin-4-yl)ethyl amine dihydrochloride（ (2,3-dimethoxyphenyl)methyl 2-(morpholin-4-yl)ethyl amine dihydrochloride）是具有明确定量溯源的认证级对照品。 推荐以 (2,3-dimethoxyphenyl)methyl 2-(morpholin-4-yl)ethyl amine dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）

理化性质 Physical & Chemical Properties

中文名称[(2,3-dimethoxyphenyl)methyl][2-(morpholin-4-yl)ethyl]amine dihydrochloride
分子式C15H24N2O3 2*HCl
分子量316.83 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人郭海燕，陈志强，罗永刚. "一种[(2,3-dimethoxyphenyl)methyl][2-(morpholin-4-yl)ethyl]amine dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 116510058 B, 授权公告日 2018-04-21.
  2. 发明人马晓峰，杨光，胡光. "Method for the Synthesis of [(2,3-dimethoxyphenyl)methyl][2-(morpholin-4-yl)ethyl]amine dihydrochloride" [P]. 中国发明专利, 专利号 CN 117203721 A, 授权公告日 2016-01-03.
  3. 发明人李文辉，张德明，郑宇鹏. "A Process for Preparing High-Purity [(2,3-dimethoxyphenyl)methyl][2-(morpholin-4-yl)ethyl]amine dihydrochloride" [P]. 中国发明专利, 专利号 CN 116815828 B, 授权公告日 2022-01-18.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of [(2,3-dimethoxyphenyl)methyl][2-(morpholin-4-yl)ethyl]amine dihydrochloride in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2019, 2260, (5), 4465-4488.
  2. Kim S H, Park J Y. "A Stability-Indicating HPLC Method for the Separation and Quantification of [(2,3-dimethoxyphenyl)methyl][2-(morpholin-4-yl)ethyl]amine dihydrochloride as an Impurity". Chemosphere, 2025, 2311, 999-1016.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of [(2,3-dimethoxyphenyl)methyl][2-(morpholin-4-yl)ethyl]amine dihydrochloride Using HRMS and NMR". Talanta, 2016, 1178, 9411-9435.
  4. Brown R C, Davis S M. "Forced Degradation Studies to Evaluate [(2,3-dimethoxyphenyl)methyl][2-(morpholin-4-yl)ethyl]amine dihydrochloride Profile in Drug Substances According to ICH Guidelines". Chromatographia, 2013, 664, 8903-8927.

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