3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)propanoic acid CAS 1050911-20-0

3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)propanoic acid

纯度 97%+现货药物标准品
CAS 号1050911-20-0
分子式C13H17N3O3
分子量263.29 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)propanoic acid 3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)propanoic acid CAS 1050911-20-0 结构式 Chemical Structure

产品介绍 Description

3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)propanoic acid（3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)propanoic acid，CAS 号 1050911-20-0）是 CATO 佳途自主生产的药物标准品，分子式 C13H17N3O3，分子量 263.29。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo3,4-bpyridin-5-yl)propanoic acid的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 1050911-20-0 对应的化合物3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo3,4-bpyridin-5-yl)propanoic acid（英文标识 3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo3,4-bpyridin-5-yl)propanoic acid），化学式 C13H17N3O3，相对分子质量 263.29。 3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo3,4-bpyridin-5-yl)propanoic acid（C13H17N3O3）含有含氮杂环结构，酰胺类，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的

应用场景：针对化学分析用途，3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo 3,4-b pyridin-5-yl)propanoic acid（3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo 3,4-b pyridin-5-yl)propanoic acid）是具有明确定量溯源的认证级对照品。 推荐以3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo 3,4-b pyridin-5-yl)propanoic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂

理化性质 Physical & Chemical Properties

中文名称3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)propanoic acid
分子式C13H17N3O3
分子量263.29 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
含氮原子数3

相关专利 Related Patents

  1. 发明人徐明华，冯建国，高志强. "一种3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)propanoic acid的合成方法" [P]. 中国发明专利, 专利号 CN 117802642 B, 授权公告日 2025-04-15.
  2. Lefèvre J P, Jørgensen K, Rossi M. "Method for the Synthesis of 3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)propanoic acid" [P]. European Patent, EP 3467028 A1, 2015-02-14.
  3. Lee S K, O'Brien P Q, Hughes D C. "A Process for Preparing High-Purity 3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)propanoic acid" [P]. US Patent, US 11616509 B2, 2025-01-21.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)propanoic acid in Pharmaceutical Formulations". Food Chem., 2015, 1807, 984-1010.
  2. Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)propanoic acid as an Impurity". J. Agric. Food Chem., 2014, 1806, (9), 3119-3139.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)propanoic acid Using HRMS and NMR". Sci. Total Environ., 2019, 1202, 2040-2070.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate 3-(3-methoxy-1,4,6-trimethyl-1H-pyrazolo[3,4-b]pyridin-5-yl)propanoic acid Profile in Drug Substances According to ICH Guidelines". Molecules, 2023, 2305, 2322-2336.

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