2-[4-(chloroacetyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide hydrochloride CAS 1051366-59-6

2-[4-(chloroacetyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide hydrochloride

纯度 97%+现货药物标准品
CAS 号1051366-59-6
分子式C15H20ClN3O2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-[4-(chloroacetyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide hydrochloride 2-[4-(chloroacetyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide hydrochloride CAS 1051366-59-6 结构式 Chemical Structure

产品介绍 Description

2-[4-(chloroacetyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide hydrochloride（英文名 2-[4-(chloroacetyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide hydrochloride，CAS 1051366-59-6）属于药物标准品。分子式 C15H20ClN3O2 HCl。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

2-4-(chloroacetyl)piperazin-1-yl-N-(4-methylphenyl)acetamide hydrochloride的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 2-4-(chloroacetyl)piperazin-1-yl-N-(4-methylphenyl)acetamide hydrochloride（2-4-(chloroacetyl)piperazin-1-yl-N-(4-methylphenyl)acetamide hydrochloride），CAS注册编号 1051366-59-6，化学分子式为 C15H20ClN3O2 HCl，分子量 346.25 g/mol。 依据分子式为 C15H20ClN3O2 HCl 的2-4-(chloroacetyl)piperazin-1-yl-N-(4-methylphenyl)acetamide hydrochloride结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代

应用场景：在化学分析实验室中，2- 4-(chloroacetyl)piperazin-1-yl -N-(4-methylphenyl)acetamide hydrochloride（CAS 1051366-59-6）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以2- 4-(chloroacetyl)piperazin-1-yl -N-(4-methylphenyl)acetamide hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品

理化性质 Physical & Chemical Properties

中文名称2-[4-(chloroacetyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide hydrochloride
分子式C15H20ClN3O2 HCl
分子量346.25 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1988年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人胡光，郭海燕，钱学锋. "一种2-[4-(chloroacetyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 115237612 A, 授权公告日 2015-07-01.
  2. Yamamoto T, Anderson J P, Brown S R. "Method for the Synthesis of 2-[4-(chloroacetyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide hydrochloride" [P]. US Patent, US 11014753 B2, 2017-09-23.
  3. Schröder R, Nielsen H, Johansson L. "A Process for Preparing High-Purity 2-[4-(chloroacetyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide hydrochloride" [P]. European Patent, EP 3346364 A1, 2020-07-24.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of 2-[4-(chloroacetyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide hydrochloride in Pharmaceutical Formulations". J. Agric. Food Chem., 2012, 2012, (5), 8145-8168.
  2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-[4-(chloroacetyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide hydrochloride as an Impurity". Rapid Commun. Mass Spectrom., 2021, 1504, (11), 3961-3967.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 2-[4-(chloroacetyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide hydrochloride Using HRMS and NMR". Phytochemistry, 2023, 1097, (12), 6916-6919.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate 2-[4-(chloroacetyl)piperazin-1-yl]-N-(4-methylphenyl)acetamide hydrochloride Profile in Drug Substances According to ICH Guidelines". Environ. Sci. Technol., 2020, 1323, 4088-4112.

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