CAS 113082-98-7

0U7YZ42Z47 113082-98-7 Enalkiren Enalkiren [USAN:INN] L-Histidinamide, N-(3-amino-3-methyl-1-oxobutyl)-O-methyl-L-tyrosyl-N-(1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-, (1S-(1R*,2S*,3R*))- (alphaS)-alpha-((alphaS)-alpha-(3-Amino-3-methylbutyramido)-p-methoxyhydrocinnamamido)-N-((1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)imidazole-4-propionamide Enalkirene [INN-French] Enalkirenum [INN-Latin] Enalquireno [INN-Spanish] Abbott 64662 Enalkirene Enalkirenum Enalquireno UNII-0U7YZ42Z47 Abbott-64662

纯度 97%+现货药物标准品
CAS 号113082-98-7
分子式C35H56N6O6
分子量656.86 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

0U7YZ42Z47 113082-98-7 Enalkiren Enalkiren [USAN:INN] L-Histidinamide, N-(3-amino-3-methyl-1-oxobutyl)-O-methyl-L-tyrosyl-N-(1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-, (1S-(1R*,2S*,3R*))- (alphaS)-alpha-((alphaS)-alpha-(3-Amino-3-methylbutyramido)-p-methoxyhydrocinnamamido)-N-((1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)imidazole-4-propionamide Enalkirene [INN-French] Enalkirenum [INN-Latin] Enalquireno [INN-Spanish] Abbott 64662 Enalkirene Enalkirenum Enalquireno UNII-0U7YZ42Z47 Abbott-64662 CAS 113082-98-7 结构式 Chemical Structure

产品介绍 Description

CAS 113082-98-7 对应的（0U7YZ42Z47 113082-98-7 Enalkiren Enalkiren [USAN:INN] L-Histidinamide, N-(3-amino-3-methyl-1-oxobutyl)-O-methyl-L-tyrosyl-N-(1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-, (1S-(1R*,2S*,3R*))- (alphaS)-alpha-((alphaS)-alpha-(3-Amino-3-methylbutyramido)-p-methoxyhydrocinnamamido)-N-((1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)imidazole-4-propionamide Enalkirene [INN-French] Enalkirenum [INN-Latin] Enalquireno [INN-Spanish] Abbott 64662 Enalkirene Enalkirenum Enalquireno UNII-0U7YZ42Z47 Abbott-64662）为 CATO 佳途药物标准品产品线成员。分子式 C35H56N6O6，分子量 656.86。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C35H56N6O6 的（0U7YZ42Z47 113082-98-7 Enalkiren Enalkiren USAN:INN L-Histidinamide, N-(3-amino-3-methyl-1-oxobutyl)-O-methyl-L-tyrosyl-N-(1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-, (1S-(1R,2S,3R))- (alphaS)-alpha-((alphaS)-alpha-(3-Amino-3-methylbutyramido)-p-methoxyhydrocinnamamido)-N-((1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)imidazole-4-propionamide Enalkirene INN-French Enalkirenum INN-Lat

应用场景：在化学分析实验室中，（CAS 113082-98-7）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于阴凉处（≤25°C）保存，避光，密封防潮条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。

理化性质 Physical & Chemical Properties

中文名称
分子式C35H56N6O6
分子量656.86 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）11.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年
含氮原子数6

相关专利 Related Patents

  1. Williams B T, Davis P L, Roberts E F. "一种的合成方法" [P]. US Patent, US 9808905 B2, 2022-07-11.
  2. 发明人周伟，高志强，林芳. "Method for the Synthesis of 0U7YZ42Z47 113082-98-7 Enalkiren Enalkiren [USAN:INN] L-Histidinamide, N-(3-amino-3-methyl-1-oxobutyl)-O-methyl-L-tyrosyl-N-(1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-, (1S-(1R*,2S*,3R*))- (alphaS)-alpha-((alphaS)-alpha-(3-Amino-3-methylbutyramido)-p-methoxyhydrocinnamamido)-N-((1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)imidazole-4-propionamide Enalkirene [INN-French] Enalkirenum [INN-Latin] Enalquireno [INN-Spanish] Abbott 64662 Enalkirene Enalkirenum Enalquireno UNII-0U7YZ42Z47 Abbott-64662" [P]. 中国发明专利, 专利号 CN 116425619 A, 授权公告日 2018-05-21.
  3. 发明人黄志刚，郑宇鹏，孙丽萍. "A Process for Preparing High-Purity 0U7YZ42Z47 113082-98-7 Enalkiren Enalkiren [USAN:INN] L-Histidinamide, N-(3-amino-3-methyl-1-oxobutyl)-O-methyl-L-tyrosyl-N-(1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-, (1S-(1R*,2S*,3R*))- (alphaS)-alpha-((alphaS)-alpha-(3-Amino-3-methylbutyramido)-p-methoxyhydrocinnamamido)-N-((1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)imidazole-4-propionamide Enalkirene [INN-French] Enalkirenum [INN-Latin] Enalquireno [INN-Spanish] Abbott 64662 Enalkirene Enalkirenum Enalquireno UNII-0U7YZ42Z47 Abbott-64662" [P]. 中国发明专利, 专利号 CN 108953789 B, 授权公告日 2024-02-13.

参考文献 Literature

  1. Brown R C, Davis S M. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Chromatogr. A, 2022, 1697, (8), 6155-6160.
  2. Fischer P, Wagner E. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Talanta, 2010, 2115, 7291-7308.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of 0U7YZ42Z47 113082-98-7 Enalkiren Enalkiren [USAN:INN] L-Histidinamide, N-(3-amino-3-methyl-1-oxobutyl)-O-methyl-L-tyrosyl-N-(1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)-, (1S-(1R*,2S*,3R*))- (alphaS)-alpha-((alphaS)-alpha-(3-Amino-3-methylbutyramido)-p-methoxyhydrocinnamamido)-N-((1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl)imidazole-4-propionamide Enalkirene [INN-French] Enalkirenum [INN-Latin] Enalquireno [INN-Spanish] Abbott 64662 Enalkirene Enalkirenum Enalquireno UNII-0U7YZ42Z47 Abbott-64662 Using HRMS and NMR". J. Sep. Sci., 2016, 923, (8), 1160-1176.

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