CAS 113145-69-0

113145-69-0 1G8C7QS9SR Niguldipine hydrochloride UNII-1G8C7QS9SR (+)-Niguldipine hydrochloride (S)-Niguldipine hydrochloride 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(3-(4,4-diphenyl-1-piperidinyl)propyl) 5-methyl ester, hydrochloride (1:1), (4S)- B-8509-034 BY-934

纯度 97%+现货药物标准品
CAS 号113145-69-0
分子式C36H39N3O6 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

113145-69-0 1G8C7QS9SR Niguldipine hydrochloride UNII-1G8C7QS9SR (+)-Niguldipine hydrochloride (S)-Niguldipine hydrochloride 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(3-(4,4-diphenyl-1-piperidinyl)propyl) 5-methyl ester, hydrochloride (1:1), (4S)- B-8509-034 BY-934 CAS 113145-69-0 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品（113145-69-0 1G8C7QS9SR Niguldipine hydrochloride UNII-1G8C7QS9SR (+)-Niguldipine hydrochloride (S)-Niguldipine hydrochloride 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(3-(4,4-diphenyl-1-piperidinyl)propyl) 5-methyl ester, hydrochloride (1:1), (4S)- B-8509-034 BY-934，CAS 113145-69-0），分子式 C36H39N3O6 HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括在内的目标物的控制。 化学式为 C36H39N3O6 HCl 的（113145-69-0 1G8C7QS9SR Niguldipine hydrochloride UNII-1G8C7QS9SR (+)-Niguldipine hydrochloride (S)-Niguldipine hydrochloride 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(3-(4,4-diphenyl-1-piperidinyl)propyl) 5-methyl ester, hydrochloride (1:1), (4S)- B-8509-034 BY-934），其CAS登记号是 113145-69-0，分子量为 646.18 g/mol。 依据分子式为 C36H39N3O6 HCl 的结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键，含氯取代，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 646.1

应用场景：（113145-69-0 1G8C7QS9SR Niguldipine hydrochloride UNII-1G8C7QS9SR (+)-Niguldipine hydrochloride (S)-Niguldipine hydrochloride 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(3-(4,4-diphenyl-1-piperidinyl)propyl) 5-methyl ester, hydrochloride (1:1), (4S)- B-8509-034 BY-

理化性质 Physical & Chemical Properties

中文名称
分子式C36H39N3O6 HCl
分子量646.18 g/mol
外观形态淡黄色至黄色无定形粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）18.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1989年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. Thompson G K, Williams B T, Lee S K. "一种的合成方法" [P]. US Patent, US 9214297 B2, 2018-10-13.
  2. Chen K W, Klinger H, Johnson M A. "Method for the Synthesis of 113145-69-0 1G8C7QS9SR Niguldipine hydrochloride UNII-1G8C7QS9SR (+)-Niguldipine hydrochloride (S)-Niguldipine hydrochloride 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(3-(4,4-diphenyl-1-piperidinyl)propyl) 5-methyl ester, hydrochloride (1:1), (4S)- B-8509-034 BY-934" [P]. US Patent, US 11135028 B2, 2024-01-02.

参考文献 Literature

  1. Mueller T, Schmidt R K. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Biomed. Chromatogr., 2014, 2271, (2), 5634-5637.
  2. Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Phytochemistry, 2018, 441, (8), 3321-3344.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of 113145-69-0 1G8C7QS9SR Niguldipine hydrochloride UNII-1G8C7QS9SR (+)-Niguldipine hydrochloride (S)-Niguldipine hydrochloride 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-(3-(4,4-diphenyl-1-piperidinyl)propyl) 5-methyl ester, hydrochloride (1:1), (4S)- B-8509-034 BY-934 Using HRMS and NMR". J. Agric. Food Chem., 2019, 2012, 7529-7532.

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