rac-4,4,5,5-tetramethyl-2-[(1R,2R)-2-phenylcyclopropyl]-1,3,2-dioxaborolane CAS 1240492-27-6

rac-4,4,5,5-tetramethyl-2-[(1R,2R)-2-phenylcyclopropyl]-1,3,2-dioxaborolane

纯度 97%+现货药物标准品
CAS 号1240492-27-6
分子式C15H21BO2
分子量244.14 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-4,4,5,5-tetramethyl-2-[(1R,2R)-2-phenylcyclopropyl]-1,3,2-dioxaborolane rac-4,4,5,5-tetramethyl-2-[(1R,2R)-2-phenylcyclopropyl]-1,3,2-dioxaborolane CAS 1240492-27-6 结构式 Chemical Structure

产品介绍 Description

CAS 1240492-27-6 对应的rac-4,4,5,5-tetramethyl-2-[(1R,2R)-2-phenylcyclopropyl]-1,3,2-dioxaborolane（rac-4,4,5,5-tetramethyl-2-[(1R,2R)-2-phenylcyclopropyl]-1,3,2-dioxaborolane）为 CATO 佳途药物标准品产品线成员。分子式 C15H21BO2，分子量 244.14。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

rac-4,4,5,5-tetramethyl-2-(1R,2R)-2-phenylcyclopropyl-1,3,2-dioxaborolane的产生途径与其化学式中羧酸类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 rac-4,4,5,5-tetramethyl-2-(1R,2R)-2-phenylcyclopropyl-1,3,2-dioxaborolane（rac-4,4,5,5-tetramethyl-2-(1R,2R)-2-phenylcyclopropyl-1,3,2-dioxaborolane），CAS注册编号 1240492-27-6，化学分子式为 C15H21BO2，分子量 244.14 g/mol。 rac-4,4,5,5-tetramethyl-2-(1R,2R)-2-phenylcyclopropyl-1,3,2-dioxaborolane（C15H21BO2）含有羧酸类，含羟基，含醚键。较高的碳氢比使其脂溶性较好，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策

应用场景：针对化学分析用途，rac-4,4,5,5-tetramethyl-2- (1R,2R)-2-phenylcyclopropyl -1,3,2-dioxaborolane（rac-4,4,5,5-tetramethyl-2- (1R,2R)-2-phenylcyclopropyl -1,3,2-dioxaborolane）是具有明确定量溯源的认证级对照品。 推荐以rac-4,4,5,5-tetramethyl-2- (1R,2R)-2-phenylcyclopropyl -1,3,2-dioxaborolane配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶

理化性质 Physical & Chemical Properties

中文名称rac-4,4,5,5-tetramethyl-2-[(1R,2R)-2-phenylcyclopropyl]-1,3,2-dioxaborolane
分子式C15H21BO2
分子量244.14 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件室温保存
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1990年

相关专利 Related Patents

  1. 发明人赵玉洁，沈红梅，郑宇鹏. "一种rac-4,4,5,5-tetramethyl-2-[(1R,2R)-2-phenylcyclopropyl]-1,3,2-dioxaborolane的合成方法" [P]. 中国发明专利, 专利号 CN 113153149 B, 授权公告日 2019-09-11.
  2. Nowak P, Schröder R, Björnsson E. "Method for the Synthesis of rac-4,4,5,5-tetramethyl-2-[(1R,2R)-2-phenylcyclopropyl]-1,3,2-dioxaborolane" [P]. European Patent, EP 3276720 A1, 2017-06-03.
  3. 发明人陈志强，冯建国，孙丽萍. "A Process for Preparing High-Purity rac-4,4,5,5-tetramethyl-2-[(1R,2R)-2-phenylcyclopropyl]-1,3,2-dioxaborolane" [P]. 中国发明专利, 专利号 CN 112697014 B, 授权公告日 2019-10-23.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of rac-4,4,5,5-tetramethyl-2-[(1R,2R)-2-phenylcyclopropyl]-1,3,2-dioxaborolane in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2022, 785, (7), 2639-2667.
  2. Xu M, Hu Y, Zhou D. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-4,4,5,5-tetramethyl-2-[(1R,2R)-2-phenylcyclopropyl]-1,3,2-dioxaborolane as an Impurity". Food Chem., 2021, 181, (4), 8467-8489.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of rac-4,4,5,5-tetramethyl-2-[(1R,2R)-2-phenylcyclopropyl]-1,3,2-dioxaborolane Using HRMS and NMR". Chromatographia, 2019, 1652, 7247-7262.
  4. Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate rac-4,4,5,5-tetramethyl-2-[(1R,2R)-2-phenylcyclopropyl]-1,3,2-dioxaborolane Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2014, 2374, 5610-5632.

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