5-methyl-5-[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]imidazolidine-2,4-dione CAS 1240526-54-8

5-methyl-5-[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]imidazolidine-2,4-dione

纯度 97%+现货药物标准品
CAS 号1240526-54-8
分子式C13H13N3O4
分子量275.26 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-methyl-5-[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]imidazolidine-2,4-dione 5-methyl-5-[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]imidazolidine-2,4-dione CAS 1240526-54-8 结构式 Chemical Structure

产品介绍 Description

CAS 1240526-54-8 对应的5-methyl-5-[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]imidazolidine-2,4-dione（5-methyl-5-[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]imidazolidine-2,4-dione）为 CATO 佳途药物标准品产品线成员。分子式 C13H13N3O4，分子量 275.26。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

5-methyl-5-3-(2-oxo-1,3-oxazolidin-3-yl)phenylimidazolidine-2,4-dione（分子式 C13H13N3O4）的化学结构中包含含氮杂环结构，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC-UV/DAD或LC-MS方法的建立提供了重要依据。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 5-methyl-5-3-(2-oxo-1,3-oxazolidin-3-yl)phenylimidazolidine-2,4-dione（5-methyl-5-3-(2-oxo-1,3-oxazolidin-3-yl)phenylimidazolidine-2,4-dione），CAS注册编号 1240526-54-8，化学分子式为 C13H13N3O4，分子量 275.26 g/mol。 本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考

应用场景：针对化学分析用途，5-methyl-5- 3-(2-oxo-1,3-oxazolidin-3-yl)phenyl imidazolidine-2,4-dione（5-methyl-5- 3-(2-oxo-1,3-oxazolidin-3-yl)phenyl imidazolidine-2,4-dione）是具有明确定量溯源的认证级对照品。 推荐以5-methyl-5- 3-(2-oxo-1,3-oxazolidin-3-yl)phenyl imidazolidine-2,4-dione配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据

理化性质 Physical & Chemical Properties

中文名称5-methyl-5-[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]imidazolidine-2,4-dione
分子式C13H13N3O4
分子量275.26 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1990年
含氮原子数3

相关专利 Related Patents

  1. Patel M V, Fischer A B, Yamamoto T. "一种5-methyl-5-[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]imidazolidine-2,4-dione的合成方法" [P]. US Patent, US 11424658 B2, 2020-12-03.
  2. 发明人何建平，郑宇鹏，王建平. "Method for the Synthesis of 5-methyl-5-[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]imidazolidine-2,4-dione" [P]. 中国发明专利, 专利号 CN 115227189 A, 授权公告日 2022-06-21.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 5-methyl-5-[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]imidazolidine-2,4-dione in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2010, 2378, (9), 8858-8883.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-methyl-5-[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]imidazolidine-2,4-dione as an Impurity". J. Sep. Sci., 2019, 1237, (12), 1839-1847.
  3. Kim S H, Park J Y. "Identification and Structural Characterization of a Novel Degradation Product of 5-methyl-5-[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]imidazolidine-2,4-dione Using HRMS and NMR". J. Pharm. Biomed. Anal., 2024, 1990, (8), 7978-8002.
  4. Garcia M, Rodriguez P. "Forced Degradation Studies to Evaluate 5-methyl-5-[3-(2-oxo-1,3-oxazolidin-3-yl)phenyl]imidazolidine-2,4-dione Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2015, 1220, 2541-2552.

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