Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-Azaspiro[Bicyclo[2.2.1]Heptane-7,4'-Piperidine]-1',2,3-Tricarboxylate CAS 1250997-96-6

Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-Azaspiro[Bicyclo[2.2.1]Heptane-7,4'-Piperidine]-1',2,3-Tricarboxylate

纯度 97%+现货药物标准品
CAS 号1250997-96-6
分子式C26H36N2O6
分子量472.57 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-Azaspiro[Bicyclo[2.2.1]Heptane-7,4'-Piperidine]-1',2,3-Tricarboxylate Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-Azaspiro[Bicyclo[2.2.1]Heptane-7,4'-Piperidine]-1',2,3-Tricarboxylate CAS 1250997-96-6 结构式 Chemical Structure

产品介绍 Description

CAS 1250997-96-6 对应的Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-Azaspiro[Bicyclo[2.2.1]Heptane-7,4'-Piperidine]-1',2,3-Tricarboxylate（Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-Azaspiro[Bicyclo[2.2.1]Heptane-7,4'-Piperidine]-1',2,3-Tricarboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C26H36N2O6，分子量 472.57。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-AzaspiroBicyclo2.2.1Heptane-7,4'-Piperidine-1',2,3-Tricarboxylate（Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-AzaspiroBicyclo2.2.1Heptane-7,4'-Piperidine-1',2,3-Tricarboxylate），CAS注册编号 1250997-96-6，化学分子式为 C26H36N2O6，分子量 472.57 g/mol。 依据分子式为 C26H36N2O6 的Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-AzaspiroBicyclo2.2.1Heptane-7,4'-Piperidine-1',2,3-Tricarboxylate结构特征，其分子内含甾体骨架，酰胺类，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 4

应用场景：Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-Azaspiro Bicyclo 2.2.1 Heptane-7,4'-Piperidine -1',2,3-Tricarboxylate（Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-Azaspiro Bicyclo 2.2.1 Heptane-7,4'-Piperidine -1',2,3-Tricarboxylate）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以Racemic-(1S,3S,4R)-2-Benz

理化性质 Physical & Chemical Properties

中文名称Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-Azaspiro[Bicyclo[2.2.1]Heptane-7,4'-Piperidine]-1',2,3-Tricarboxylate
分子式C26H36N2O6
分子量472.57 g/mol
外观形态淡黄色至黄色结晶性粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1990年
含氮原子数2

相关专利 Related Patents

  1. Stevens L M, Roberts E F, Anderson J P. "一种Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-Azaspiro[Bicyclo[2.2.1]Heptane-7,4'-Piperidine]-1',2,3-Tricarboxylate的合成方法" [P]. US Patent, US 9692835 B2, 2022-05-24.
  2. 发明人何建平，韩伟，高志强. "Method for the Synthesis of Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-Azaspiro[Bicyclo[2.2.1]Heptane-7,4'-Piperidine]-1',2,3-Tricarboxylate" [P]. 中国发明专利, 专利号 CN 116040324 A, 授权公告日 2015-01-10.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-Azaspiro[Bicyclo[2.2.1]Heptane-7,4'-Piperidine]-1',2,3-Tricarboxylate in Pharmaceutical Formulations". Sci. Total Environ., 2017, 1184, 5245-5268.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-Azaspiro[Bicyclo[2.2.1]Heptane-7,4'-Piperidine]-1',2,3-Tricarboxylate as an Impurity". Anal. Methods, 2010, 767, 7946-7971.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-Azaspiro[Bicyclo[2.2.1]Heptane-7,4'-Piperidine]-1',2,3-Tricarboxylate Using HRMS and NMR". J. Nat. Prod., 2020, 97, 8988-8996.
  4. Wang L, Li J, Zhang H. "Forced Degradation Studies to Evaluate Racemic-(1S,3S,4R)-2-Benzyl 1'-Tert-Butyl 3-Ethyl 2-Azaspiro[Bicyclo[2.2.1]Heptane-7,4'-Piperidine]-1',2,3-Tricarboxylate Profile in Drug Substances According to ICH Guidelines". Phytochemistry, 2019, 1598, (6), 3396-3425.

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