CAS 127126-22-1

127126-22-1 1T7773JH5N 5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride, (S)- UNII-1T7773JH5N 1-Naphthalenol, 7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydro-, hydrochloride (1:1), (7S)- (S)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride (S)-(-)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride

纯度 97%+现货药物标准品
CAS 号127126-22-1
分子式C16H24FNO HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

127126-22-1 1T7773JH5N 5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride, (S)- UNII-1T7773JH5N 1-Naphthalenol, 7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydro-, hydrochloride (1:1), (7S)- (S)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride (S)-(-)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride CAS 127126-22-1 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品（127126-22-1 1T7773JH5N 5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride, (S)- UNII-1T7773JH5N 1-Naphthalenol, 7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydro-, hydrochloride (1:1), (7S)- (S)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride (S)-(-)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride，CAS 127126-22-1），分子式 C16H24FNO HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

与同类药物标准品相比，的分子量为301.83 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 （127126-22-1 1T7773JH5N 5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride, (S)- UNII-1T7773JH5N 1-Naphthalenol, 7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydro-, hydrochloride (1:1), (7S)- (S)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride (S)-(-)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride），CAS注册编号 127126-22-1，化学分子式为 C16H24FNO HCl，分子量 301.83 g/mol。 （C16H24FNO HCl）含有含氮杂环结构，酰胺类，含羟基，含醚键，含氟/氯取代。卤素取代增加了化合物的

应用场景：针对化学分析用途，（127126-22-1 1T7773JH5N 5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride, (S)- UNII-1T7773JH5N 1-Naphthalenol, 7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydro-, hydrochloride (1:1), (7S)- (S)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride (S)-(-)-5-Fluoro-8-hydroxy-2-(di

理化性质 Physical & Chemical Properties

中文名称
分子式C16H24FNO HCl
分子量301.83 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于氯仿、二氯甲烷、乙酸乙酯、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1993年
卤素含量F/Cl取代
含氮原子数1

相关专利 Related Patents

  1. 发明人张德明，罗永刚，杨光. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 109978685 B, 授权公告日 2019-01-08.
  2. Thompson G K, Patel M V, Johnson M A. "Method for the Synthesis of 127126-22-1 1T7773JH5N 5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride, (S)- UNII-1T7773JH5N 1-Naphthalenol, 7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydro-, hydrochloride (1:1), (7S)- (S)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride (S)-(-)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride" [P]. US Patent, US 9917509 B2, 2015-12-25.
  3. Williams B T, Park J H, Brown S R. "A Process for Preparing High-Purity 127126-22-1 1T7773JH5N 5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride, (S)- UNII-1T7773JH5N 1-Naphthalenol, 7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydro-, hydrochloride (1:1), (7S)- (S)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride (S)-(-)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride" [P]. US Patent, US 9613148 B2, 2022-05-04.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Chromatographia, 2010, 1508, (7), 5446-5472.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Anal. Methods, 2017, 542, 5452-5480.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 127126-22-1 1T7773JH5N 5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride, (S)- UNII-1T7773JH5N 1-Naphthalenol, 7-(dipropylamino)-4-fluoro-5,6,7,8-tetrahydro-, hydrochloride (1:1), (7S)- (S)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride (S)-(-)-5-Fluoro-8-hydroxy-2-(dipropylamino)tetralin hydrochloride Using HRMS and NMR". Talanta, 2014, 337, (4), 3101-3123.
  4. Yamamoto K, Tanaka H, Suzuki T. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2023, 997, (3), 4556-4577.

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