phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate CAS 1281055-79-5

phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate

纯度 97%+现货药物标准品
CAS 号1281055-79-5
分子式C21H16N4O2S
分子量388.44 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate CAS 1281055-79-5 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate（phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate，CAS 1281055-79-5），分子式 C21H16N4O2S，分子量 388.44。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

在质量保证方面，phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate（phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate），CAS注册编号 1281055-79-5，化学分子式为 C21H16N4O2S，分子量 388.44 g/mol。 从化学结构特征来看，phenyl(pyridin-4-yl)methyl 4-methyl-2-(py

应用场景：phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate（phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法

理化性质 Physical & Chemical Properties

中文名称phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate
分子式C21H16N4O2S
分子量388.44 g/mol
外观形态淡黄色至黄色结晶性粉末。（含硫化合物特征性气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）16.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1990年
含氮原子数4
含硫原子数1

相关专利 Related Patents

  1. Nielsen H, Nowak P, Schröder R. "一种phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate的合成方法" [P]. European Patent, EP 3767287 A1, 2019-05-09.
  2. 发明人赵玉洁，马晓峰，沈红梅. "Method for the Synthesis of phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate" [P]. 中国发明专利, 专利号 CN 110181169 A, 授权公告日 2022-11-27.
  3. 发明人杨光，冯建国，沈红梅. "A Process for Preparing High-Purity phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate" [P]. 中国发明专利, 专利号 CN 112522304 B, 授权公告日 2015-11-18.

参考文献 Literature

  1. Smith J A, Johnson M B. "Development and Validation of an LC-MS/MS Method for the Determination of phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate in Pharmaceutical Formulations". J. Chromatogr. A, 2020, 1887, 4752-4766.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate as an Impurity". J. Agric. Food Chem., 2015, 1563, 1825-1833.
  3. Smith J A, Johnson M B. "Identification and Structural Characterization of a Novel Degradation Product of phenyl(pyridin-4-yl)methyl 4-methyl-2-(pyrimidin-2-yl)-1,3-thiazole-5-carboxylate Using HRMS and NMR". Chemosphere, 2012, 1795, 9734-9748.

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