CAS 1310404-53-5

1310404-53-5 5-tert-Butyloxycarbonylamino-2-chloropyridine-3-boronic acid pinacol ester N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]carbamic acid tert-butyl ester N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridyl]carbamic acid tert-butyl ester tert-butyl N-[6-chloranyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]carbamate tert-butyl N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridyl]carbamate tert-butyl N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]carbamate

纯度 97%+现货药物标准品
CAS 号1310404-53-5
分子式C16H24BClN2O4
分子量354.64 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1310404-53-5 5-tert-Butyloxycarbonylamino-2-chloropyridine-3-boronic acid pinacol ester N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]carbamic acid tert-butyl ester N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridyl]carbamic acid tert-butyl ester tert-butyl N-[6-chloranyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]carbamate tert-butyl N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridyl]carbamate tert-butyl N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]carbamate CAS 1310404-53-5 结构式 Chemical Structure

产品介绍 Description

（英文名 1310404-53-5 5-tert-Butyloxycarbonylamino-2-chloropyridine-3-boronic acid pinacol ester N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]carbamic acid tert-butyl ester N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridyl]carbamic acid tert-butyl ester tert-butyl N-[6-chloranyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]carbamate tert-butyl N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridyl]carbamate tert-butyl N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]carbamate，CAS 1310404-53-5）属于药物标准品。分子式 C16H24BClN2O4，分子量 354.64。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在质量保证方面，的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 CAS编号 1310404-53-5 对应的化合物（英文标识 1310404-53-5 5-tert-Butyloxycarbonylamino-2-chloropyridine-3-boronic acid pinacol ester N-6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinylcarbamic acid tert-butyl ester N-6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridylcarbamic acid tert-butyl ester tert-butyl N-6-chloranyl-5-(4,4,

应用场景：（1310404-53-5 5-tert-Butyloxycarbonylamino-2-chloropyridine-3-boronic acid pinacol ester N- 6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl carbamic acid tert-butyl ester N- 6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridyl carbamic acid tert-butyl ester tert-bu

理化性质 Physical & Chemical Properties

中文名称
分子式C16H24BClN2O4
分子量354.64 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1990年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人林芳，徐明华，陈志强. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 112886095 B, 授权公告日 2023-10-08.
  2. Klinger H, Roberts E F, Lee S K. "Method for the Synthesis of 1310404-53-5 5-tert-Butyloxycarbonylamino-2-chloropyridine-3-boronic acid pinacol ester N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]carbamic acid tert-butyl ester N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridyl]carbamic acid tert-butyl ester tert-butyl N-[6-chloranyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]carbamate tert-butyl N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridyl]carbamate tert-butyl N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]carbamate" [P]. US Patent, US 11583698 B2, 2024-09-02.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Nat. Prod., 2013, 1531, (6), 2953-2968.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Anal. Chim. Acta, 2010, 2419, 2944-2953.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 1310404-53-5 5-tert-Butyloxycarbonylamino-2-chloropyridine-3-boronic acid pinacol ester N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridinyl]carbamic acid tert-butyl ester N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridyl]carbamic acid tert-butyl ester tert-butyl N-[6-chloranyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]carbamate tert-butyl N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3-pyridyl]carbamate tert-butyl N-[6-chloro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl]carbamate Using HRMS and NMR". J. Sep. Sci., 2019, 85, 4345-4368.

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