Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino[5,4-C]Pyrazole-10-Carboxylate CAS 1311183-41-1

Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino[5,4-C]Pyrazole-10-Carboxylate

纯度 97%+现货药物标准品
CAS 号1311183-41-1
分子式C13H19N3O3
分子量265.31 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino[5,4-C]Pyrazole-10-Carboxylate Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino[5,4-C]Pyrazole-10-Carboxylate CAS 1311183-41-1 结构式 Chemical Structure

产品介绍 Description

Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino[5,4-C]Pyrazole-10-Carboxylate（Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino[5,4-C]Pyrazole-10-Carboxylate，CAS 号 1311183-41-1）是 CATO 佳途自主生产的药物标准品，分子式 C13H19N3O3，分子量 265.31。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino5,4-CPyrazole-10-Carboxylate（Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino5,4-CPyrazole-10-Carboxylate），CAS注册编号 1311183-41-1，化学分子式为 C13H19N3O3，分子量 265.31 g/mol。 从化学结构特征来看，Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino5,4-CPyrazole-10-Carboxylate的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键。该化合物的不饱和度为6.0，表明结构中存在约6个环或双键等价单元。分子量为265.31 g/mol，属于中等分子量化合物。分子中包含芳环或共轭体系，在UV-V

应用场景：在化学分析实验室中，Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino 5,4-C Pyrazole-10-Carboxylate（CAS 1311183-41-1）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino 5,4-C Pyrazole-10-Carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议：

理化性质 Physical & Chemical Properties

中文名称Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino[5,4-C]Pyrazole-10-Carboxylate
分子式C13H19N3O3
分子量265.31 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1990年
含氮原子数3

相关专利 Related Patents

  1. Hughes D C, Park J H, Anderson J P. "一种Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino[5,4-C]Pyrazole-10-Carboxylate的合成方法" [P]. US Patent, US 11675994 B2, 2022-10-28.
  2. Schröder R, Mueller T, Chen K W. "Method for the Synthesis of Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino[5,4-C]Pyrazole-10-Carboxylate" [P]. US Patent, US 10101748 B2, 2021-05-16.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino[5,4-C]Pyrazole-10-Carboxylate in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2024, 1103, (3), 4689-4697.
  2. Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino[5,4-C]Pyrazole-10-Carboxylate as an Impurity". Chemosphere, 2013, 1778, (4), 4100-4108.
  3. Yamamoto K, Tanaka H, Suzuki T. "Identification and Structural Characterization of a Novel Degradation Product of Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino[5,4-C]Pyrazole-10-Carboxylate Using HRMS and NMR". J. Sep. Sci., 2012, 1765, (11), 6964-6987.
  4. Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate Tert-Butyl 1,4,5,7,8,9-Hexahydro-4,8-Epiminooxocino[5,4-C]Pyrazole-10-Carboxylate Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2018, 402, (5), 7921-7947.

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