CAS 1350456-56-2

[4-[[(2S)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methyl N-[(1S)-1-[[(1S)-1-[[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl]amino]-1-methoxy-2-methyl-3-oxo-propyl]pyrrolidin-1-yl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxo-butyl]-methyl-carbamoyl]-2-methyl-propyl]carbamoyl]-2-methyl-propyl]-N-methyl-carbamate

纯度 97%+现货药物标准品
CAS 号1350456-56-2
分子式C73H104N10O14
分子量1345.67 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

[4-[[(2S)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methyl N-[(1S)-1-[[(1S)-1-[[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl]amino]-1-methoxy-2-methyl-3-oxo-propyl]pyrrolidin-1-yl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxo-butyl]-methyl-carbamoyl]-2-methyl-propyl]carbamoyl]-2-methyl-propyl]-N-methyl-carbamate CAS 1350456-56-2 结构式 Chemical Structure

产品介绍 Description

（[4-[[(2S)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methyl N-[(1S)-1-[[(1S)-1-[[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl]amino]-1-methoxy-2-methyl-3-oxo-propyl]pyrrolidin-1-yl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxo-butyl]-methyl-carbamoyl]-2-methyl-propyl]carbamoyl]-2-methyl-propyl]-N-methyl-carbamate，CAS 号 1350456-56-2）是 CATO 佳途自主生产的药物标准品，分子式 C73H104N10O14，分子量 1345.67。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，的分子量为1345.67 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C73H104N10O14 的（4-(2S)-2-(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butanoylamino-5-ureido-pentanoylaminophenylmethyl N-(1S)-1-(1S)-1-(1S,2R)-4-(2S)-2-(1R,2R)-3-(1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethylamino-1-methoxy-2-methyl-3-oxo-propylpyrrolidin-1-yl-2-methoxy-1-(1S)-1-methylpropyl-4-oxo-butyl-methyl-carbamoyl-2-methyl-propylcarbamoyl-2-methyl-propyl-N-methyl-carbamate），其CAS登记号是 1350456-

应用场景：针对化学分析用途，（ 4- (2S)-2- (2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butanoyl amino -5-ureido-pentanoyl amino phenyl methyl N- (1S)-1- (1S)-1- (1S,2R)-4- (2S)-2- (1R,2R)-3- (1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl amino -1-methoxy-2-methyl-3-oxo-propyl pyrrolidin-1-yl -2-methoxy-1- (1S)

理化性质 Physical & Chemical Properties

中文名称
分子式C73H104N10O14
分子量1345.67 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）27.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
含氮原子数10

相关专利 Related Patents

  1. Schröder R, Anderson J P, Park J H. "一种的合成方法" [P]. US Patent, US 10647108 B2, 2019-12-25.
  2. 发明人马晓峰，李文辉，黄志刚. "Method for the Synthesis of [4-[[(2S)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methyl N-[(1S)-1-[[(1S)-1-[[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl]amino]-1-methoxy-2-methyl-3-oxo-propyl]pyrrolidin-1-yl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxo-butyl]-methyl-carbamoyl]-2-methyl-propyl]carbamoyl]-2-methyl-propyl]-N-methyl-carbamate" [P]. 中国发明专利, 专利号 CN 108366717 B, 授权公告日 2018-08-23.

参考文献 Literature

  1. Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Chemosphere, 2010, 1009, 9741-9767.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Phytochemistry, 2012, 2352, (12), 584-588.
  3. Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of [4-[[(2S)-2-[[(2S)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-3-methyl-butanoyl]amino]-5-ureido-pentanoyl]amino]phenyl]methyl N-[(1S)-1-[[(1S)-1-[[(1S,2R)-4-[(2S)-2-[(1R,2R)-3-[[(1R,2S)-2-hydroxy-1-methyl-2-phenyl-ethyl]amino]-1-methoxy-2-methyl-3-oxo-propyl]pyrrolidin-1-yl]-2-methoxy-1-[(1S)-1-methylpropyl]-4-oxo-butyl]-methyl-carbamoyl]-2-methyl-propyl]carbamoyl]-2-methyl-propyl]-N-methyl-carbamate Using HRMS and NMR". J. Nat. Prod., 2016, 355, 4890-4910.

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