2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-[4-[(1E)-3-[[2-(4-hydroxyphenyl)ethyl]amino]-3-oxo-1-propen-1-yl]-2-methoxyphenoxy]-, (2Z)- CAS 1374216-67-7

2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-[4-[(1E)-3-[[2-(4-hydroxyphenyl)ethyl]amino]-3-oxo-1-propen-1-yl]-2-methoxyphenoxy]-, (2Z)-

纯度 97%+现货药物标准品
CAS 号1374216-67-7
分子式C36H36N2O8
分子量624.68 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-[4-[(1E)-3-[[2-(4-hydroxyphenyl)ethyl]amino]-3-oxo-1-propen-1-yl]-2-methoxyphenoxy]-, (2Z)- 2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-[4-[(1E)-3-[[2-(4-hydroxyphenyl)ethyl]amino]-3-oxo-1-propen-1-yl]-2-methoxyphenoxy]-, (2Z)- CAS 1374216-67-7 结构式 Chemical Structure

产品介绍 Description

CAS 1374216-67-7 对应的2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-[4-[(1E)-3-[[2-(4-hydroxyphenyl)ethyl]amino]-3-oxo-1-propen-1-yl]-2-methoxyphenoxy]-, (2Z)-（2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-[4-[(1E)-3-[[2-(4-hydroxyphenyl)ethyl]amino]-3-oxo-1-propen-1-yl]-2-methoxyphenoxy]-, (2Z)-）为 CATO 佳途药物标准品产品线成员。分子式 C36H36N2O8，分子量 624.68。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

依据分子式为 C36H36N2O8 的2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N-2-(4-hydroxyphenyl)ethyl-2-4-(1E)-3-2-(4-hydroxyphenyl)ethylamino-3-oxo-1-propen-1-yl-2-methoxyphenoxy-, (2Z)-结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 624.68 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。分子中的氮原子赋予该化合物一定的碱性特征，在酸性流动相条件下可被有效质子化。 CAS编号 1374216-67-7 对应的化合物2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N-2-(4-hydroxyphenyl)ethyl-2-4-(1E)-3-2-(4-hydroxyphenyl)ethylamino-3-oxo-1-propen-1-yl-2-methoxy

应用场景：2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N- 2-(4-hydroxyphenyl)ethyl -2- 4- (1E)-3- 2-(4-hydroxyphenyl)ethyl amino -3-oxo-1-propen-1-yl -2-methoxyphenoxy -, (2Z)-（2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N- 2-(4-hydroxyphenyl)ethyl -2- 4- (1E)-3- 2-(4-hydroxyphenyl)ethyl amino -3-oxo-1-pro

理化性质 Physical & Chemical Properties

中文名称2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-[4-[(1E)-3-[[2-(4-hydroxyphenyl)ethyl]amino]-3-oxo-1-propen-1-yl]-2-methoxyphenoxy]-, (2Z)-
分子式C36H36N2O8
分子量624.68 g/mol
外观形态淡黄色至黄色无定形粉末
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）20.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
含氮原子数2

相关专利 Related Patents

  1. 发明人冯建国，杨光，沈红梅. "一种2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-[4-[(1E)-3-[[2-(4-hydroxyphenyl)ethyl]amino]-3-oxo-1-propen-1-yl]-2-methoxyphenoxy]-, (2Z)-的合成方法" [P]. 中国发明专利, 专利号 CN 113276258 A, 授权公告日 2016-10-24.
  2. 发明人沈红梅，黄志刚，罗永刚. "Method for the Synthesis of 2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-[4-[(1E)-3-[[2-(4-hydroxyphenyl)ethyl]amino]-3-oxo-1-propen-1-yl]-2-methoxyphenoxy]-, (2Z)-" [P]. 中国发明专利, 专利号 CN 108382143 B, 授权公告日 2018-09-19.
  3. 发明人沈红梅，罗永刚，赵玉洁. "A Process for Preparing High-Purity 2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-[4-[(1E)-3-[[2-(4-hydroxyphenyl)ethyl]amino]-3-oxo-1-propen-1-yl]-2-methoxyphenoxy]-, (2Z)-" [P]. 中国发明专利, 专利号 CN 113430828 B, 授权公告日 2023-05-13.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-[4-[(1E)-3-[[2-(4-hydroxyphenyl)ethyl]amino]-3-oxo-1-propen-1-yl]-2-methoxyphenoxy]-, (2Z)- in Pharmaceutical Formulations". Anal. Methods, 2018, 2269, (7), 857-875.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-Propenamide, 3-(3-hydroxy-4-methoxyphenyl)-N-[2-(4-hydroxyphenyl)ethyl]-2-[4-[(1E)-3-[[2-(4-hydroxyphenyl)ethyl]amino]-3-oxo-1-propen-1-yl]-2-methoxyphenoxy]-, (2Z)- as an Impurity". Biomed. Chromatogr., 2010, 2383, 5991-6019.

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