CAS 140187-23-1

(2S)-2-amino-3-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid (S)-(-)-5-fluorowillardiine (S)-F-Willardiine (S)-alpha-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimmidinepropanoic acid 140187-23-1 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID 3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine 3-(5-fluorouracil-1-yl)-L-alanine 5-Fluorowillardiine CHEBI:42549

纯度 97%+现货药物标准品
CAS 号140187-23-1
分子式C7H8FN3O4
分子量217.15 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

(2S)-2-amino-3-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid (S)-(-)-5-fluorowillardiine (S)-F-Willardiine (S)-alpha-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimmidinepropanoic acid 140187-23-1 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID 3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine 3-(5-fluorouracil-1-yl)-L-alanine 5-Fluorowillardiine CHEBI:42549 CAS 140187-23-1 结构式 Chemical Structure

产品介绍 Description

CAS 140187-23-1 对应的（(2S)-2-amino-3-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid (S)-(-)-5-fluorowillardiine (S)-F-Willardiine (S)-alpha-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimmidinepropanoic acid 140187-23-1 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID 3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine 3-(5-fluorouracil-1-yl)-L-alanine 5-Fluorowillardiine CHEBI:42549）为 CATO 佳途药物标准品产品线成员。分子式 C7H8FN3O4，分子量 217.15。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

（(2S)-2-amino-3-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid (S)-(-)-5-fluorowillardiine (S)-F-Willardiine (S)-alpha-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimmidinepropanoic acid 140187-23-1 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID 3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine 3-(5-fluorouracil-1-yl)-L-alanine 5-Fluorowillardiine CHEBI:42549），CAS注册编号 140187-23-1，化学分子式为 C7H8FN3O4，分子量 217.15 g/mol。 依据分子式为 C7H8FN3O4

应用场景：（(2S)-2-amino-3-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid (S)-(-)-5-fluorowillardiine (S)-F-Willardiine (S)-alpha-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimmidinepropanoic acid 140187-23-1 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID 3-(

理化性质 Physical & Chemical Properties

中文名称
分子式C7H8FN3O4
分子量217.15 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于甲醇、乙醇、DMSO、水
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1997年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. O'Brien P Q, Lee S K, Chen K W. "一种的合成方法" [P]. US Patent, US 10282735 B2, 2022-01-14.
  2. 发明人郭海燕，杨光，何建平. "Method for the Synthesis of (2S)-2-amino-3-(5-fluoro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-1-yl)propanoic acid (S)-(-)-5-fluorowillardiine (S)-F-Willardiine (S)-alpha-Amino-5-fluoro-3,4-dihydro-2,4-dioxo-1(2H)-pyrimmidinepropanoic acid 140187-23-1 2-AMINO-3-(5-FLUORO-2,4-DIOXO-3,4-DIHYDRO-2H-PYRIMIDIN-1-YL)-PROPIONIC ACID 3-(5-fluoro-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-L-alanine 3-(5-fluorouracil-1-yl)-L-alanine 5-Fluorowillardiine CHEBI:42549" [P]. 中国发明专利, 专利号 CN 113181126 A, 授权公告日 2015-04-26.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Phytochemistry, 2011, 546, (11), 8209-8237.
  2. Garcia M, Rodriguez P. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Chromatographia, 2013, 600, (4), 802-805.

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