methyl 3-[(dimethylcarbamoyl)sulfanyl]thiophene-2-carboxylate CAS 141557-41-7
methyl 3-[(dimethylcarbamoyl)sulfanyl]thiophene-2-carboxylate
| CAS 号 | 141557-41-7 |
| 分子式 | C9H11NO3S2 |
| 分子量 | 245.32 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 141557-41-7 对应的methyl 3-[(dimethylcarbamoyl)sulfanyl]thiophene-2-carboxylate（methyl 3-[(dimethylcarbamoyl)sulfanyl]thiophene-2-carboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C9H11NO3S2，分子量 245.32。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
methyl 3-(dimethylcarbamoyl)sulfanylthiophene-2-carboxylate的产生途径与其化学式中含氮杂环结构，酰胺类，含砜基，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C9H11NO3S2 的methyl 3-(dimethylcarbamoyl)sulfanylthiophene-2-carboxylate（methyl 3-(dimethylcarbamoyl)sulfanylthiophene-2-carboxylate），其CAS登记号是 141557-41-7，分子量为 245.32 g/mol。 methyl 3-(dimethylcarbamoyl)sulfanylthiophene-2-carboxylate（C9H11NO3S2）含有含氮杂环结构，酰胺类，含砜基，含羟基，含醚键。具有较强的吸湿性，羧基赋予其一定的酸性特征，这些物理化学性质直接决定了其标准溶液的最佳配制方案和储存策略。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于
应用场景：针对化学分析用途，methyl 3- (dimethylcarbamoyl)sulfanyl thiophene-2-carboxylate（methyl 3- (dimethylcarbamoyl)sulfanyl thiophene-2-carboxylate）是具有明确定量溯源的认证级对照品。 推荐以methyl 3- (dimethylcarbamoyl)sulfanyl thiophene-2-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平
理化性质 Physical & Chemical Properties
| 中文名称 | methyl 3-[(dimethylcarbamoyl)sulfanyl]thiophene-2-carboxylate |
| 分子式 | C9H11NO3S2 |
| 分子量 | 245.32 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味，含硫化合物特征性气味） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 5.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1997年 |
| 含氮原子数 | 1 |
| 含硫原子数 | 2 |
相关专利 Related Patents
- Lefèvre J P, Jørgensen K, Nowak P. "一种methyl 3-[(dimethylcarbamoyl)sulfanyl]thiophene-2-carboxylate的合成方法" [P]. European Patent, EP 3329737 A1, 2017-09-22.
- Lee S K, Roberts E F, Davis P L. "Method for the Synthesis of methyl 3-[(dimethylcarbamoyl)sulfanyl]thiophene-2-carboxylate" [P]. US Patent, US 9840171 B2, 2017-03-16.
参考文献 Literature
- Lee J H, Choi Y S. "Development and Validation of an LC-MS/MS Method for the Determination of methyl 3-[(dimethylcarbamoyl)sulfanyl]thiophene-2-carboxylate in Pharmaceutical Formulations". Molecules, 2019, 1572, 8489-8502.
- Mueller T, Schmidt R K. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl 3-[(dimethylcarbamoyl)sulfanyl]thiophene-2-carboxylate as an Impurity". J. Agric. Food Chem., 2020, 2370, (3), 6527-6530.
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