tert-butyl 3-{[methyl(pyridin-3-ylmethyl)amino]methyl}pyrrolidine-1-carboxylate CAS 1420903-01-0

tert-butyl 3-{[methyl(pyridin-3-ylmethyl)amino]methyl}pyrrolidine-1-carboxylate

纯度 97%+现货药物标准品
CAS 号1420903-01-0
分子式C17H27N3O2
分子量305.42 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

tert-butyl 3-{[methyl(pyridin-3-ylmethyl)amino]methyl}pyrrolidine-1-carboxylate tert-butyl 3-{[methyl(pyridin-3-ylmethyl)amino]methyl}pyrrolidine-1-carboxylate CAS 1420903-01-0 结构式 Chemical Structure

产品介绍 Description

CAS 1420903-01-0 对应的tert-butyl 3-{[methyl(pyridin-3-ylmethyl)amino]methyl}pyrrolidine-1-carboxylate（tert-butyl 3-{[methyl(pyridin-3-ylmethyl)amino]methyl}pyrrolidine-1-carboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C17H27N3O2，分子量 305.42。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

tert-butyl 3-{methyl(pyridin-3-ylmethyl)aminomethyl}pyrrolidine-1-carboxylate的产生途径与其化学式中甾体骨架，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 1420903-01-0 对应的化合物tert-butyl 3-{methyl(pyridin-3-ylmethyl)aminomethyl}pyrrolidine-1-carboxylate（英文标识 tert-butyl 3-{methyl(pyridin-3-ylmethyl)aminomethyl}pyrrolidine-1-carboxylate），化学式 C17H27N3O2，相对分子质量 305.42。 依据分子式为 C17H27N3O2 的tert-butyl 3-{methyl(pyridin-3-ylmethyl)aminomethyl}pyrrolidine-1-carboxylate结构特征，其分子内含甾体骨架，酰胺类，含羟基，含醚键，这意味着该化合物在紫

应用场景：针对化学分析用途，tert-butyl 3-{ methyl(pyridin-3-ylmethyl)amino methyl}pyrrolidine-1-carboxylate（tert-butyl 3-{ methyl(pyridin-3-ylmethyl)amino methyl}pyrrolidine-1-carboxylate）是具有明确定量溯源的认证级对照品。 推荐以tert-butyl 3-{ methyl(pyridin-3-ylmethyl)amino methyl}pyrrolidine-1-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议

理化性质 Physical & Chemical Properties

中文名称tert-butyl 3-{[methyl(pyridin-3-ylmethyl)amino]methyl}pyrrolidine-1-carboxylate
分子式C17H27N3O2
分子量305.42 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
含氮原子数3

相关专利 Related Patents

  1. Nowak P, Lefèvre J P, Sørensen M. "一种tert-butyl 3-{[methyl(pyridin-3-ylmethyl)amino]methyl}pyrrolidine-1-carboxylate的合成方法" [P]. European Patent, EP 3877947 A1, 2016-10-22.
  2. 发明人朱建伟，何建平，黄志刚. "Method for the Synthesis of tert-butyl 3-{[methyl(pyridin-3-ylmethyl)amino]methyl}pyrrolidine-1-carboxylate" [P]. 中国发明专利, 专利号 CN 109119585 B, 授权公告日 2020-10-20.
  3. 发明人郑宇鹏，冯建国，郭海燕. "A Process for Preparing High-Purity tert-butyl 3-{[methyl(pyridin-3-ylmethyl)amino]methyl}pyrrolidine-1-carboxylate" [P]. 中国发明专利, 专利号 CN 109453647 A, 授权公告日 2020-01-26.

参考文献 Literature

  1. Chen X Y, Liu M, Zhao W Q. "Development and Validation of an LC-MS/MS Method for the Determination of tert-butyl 3-{[methyl(pyridin-3-ylmethyl)amino]methyl}pyrrolidine-1-carboxylate in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2012, 1491, 6953-6964.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of tert-butyl 3-{[methyl(pyridin-3-ylmethyl)amino]methyl}pyrrolidine-1-carboxylate as an Impurity". Anal. Chim. Acta, 2020, 1441, (2), 679-709.

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