[8-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanamine CAS 1423034-73-4

[8-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanamine

纯度 97%+现货药物标准品
CAS 号1423034-73-4
分子式C8H11F3N4
分子量220.19 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

[8-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanamine [8-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanamine CAS 1423034-73-4 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品[8-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanamine（[8-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanamine，CAS 1423034-73-4），分子式 C8H11F3N4，分子量 220.19。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

在质量保证方面，8-(trifluoromethyl)-5H,6H,7H,8H-1,2,4triazolo4,3-apyridin-3-ylmethanamine的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 化学式为 C8H11F3N4 的8-(trifluoromethyl)-5H,6H,7H,8H-1,2,4triazolo4,3-apyridin-3-ylmethanamine（8-(trifluoromethyl)-5H,6H,7H,8H-1,2,4triazolo4,3-apyridin-3-ylmethanamine），其CAS登记号是 1423034-73-4，分子量为 220.19 g/mol。 受分子结构中含氮杂环结构，含氰基，含氟取代的影响，8-(trifluoromethyl)-5H,6H,7H,8H-

应用场景： 8-(trifluoromethyl)-5H,6H,7H,8H- 1,2,4 triazolo 4,3-a pyridin-3-yl methanamine（ 8-(trifluoromethyl)-5H,6H,7H,8H- 1,2,4 triazolo 4,3-a pyridin-3-yl methanamine，CAS 1423034-73-4）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以 8-(trifluoromethyl)-5H,6H,7H,8H- 1,2,4 triazolo 4,3-a pyridin-3-yl methanamine配制标准系列工作溶液，用于建立

理化性质 Physical & Chemical Properties

中文名称[8-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanamine
分子式C8H11F3N4
分子量220.19 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
卤素含量F取代
含氮原子数4

相关专利 Related Patents

  1. Schröder R, Williams B T, Thompson G K. "一种[8-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanamine的合成方法" [P]. US Patent, US 9766419 B2, 2020-12-05.
  2. Nowak P, Kowalski A, Mueller T C. "Method for the Synthesis of [8-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanamine" [P]. European Patent, EP 3138617 A1, 2020-06-20.
  3. Johnson M A, Chen K W, O'Brien P Q. "A Process for Preparing High-Purity [8-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanamine" [P]. US Patent, US 11516408 B2, 2024-09-27.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of [8-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanamine in Pharmaceutical Formulations". Environ. Sci. Technol., 2021, 1774, (3), 7467-7480.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of [8-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanamine as an Impurity". J. Chromatogr. A, 2018, 2463, 2950-2977.
  3. Xu M, Hu Y, Zhou D. "Identification and Structural Characterization of a Novel Degradation Product of [8-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanamine Using HRMS and NMR". Talanta, 2018, 1526, 5359-5367.
  4. O'Brien K, Kennedy M L. "Forced Degradation Studies to Evaluate [8-(trifluoromethyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridin-3-yl]methanamine Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2014, 483, 5708-5716.

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