3-methyl-1-[1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)ethyl]-1H-pyrazol-4-amine,HCl CAS 1431966-49-2

3-methyl-1-[1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)ethyl]-1H-pyrazol-4-amine,HCl

纯度 97%+现货药物标准品
CAS 号1431966-49-2
分子式C13H20N6 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

3-methyl-1-[1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)ethyl]-1H-pyrazol-4-amine,HCl 3-methyl-1-[1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)ethyl]-1H-pyrazol-4-amine,HCl CAS 1431966-49-2 结构式 Chemical Structure

产品介绍 Description

CAS 1431966-49-2 对应的3-methyl-1-[1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)ethyl]-1H-pyrazol-4-amine,HCl（3-methyl-1-[1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)ethyl]-1H-pyrazol-4-amine,HCl）为 CATO 佳途药物标准品产品线成员。分子式 C13H20N6 HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在质量保证方面，3-methyl-1-1-(6,7,8,9-tetrahydro-5H-1,2,4triazolo4,3-aazepin-3-yl)ethyl-1H-pyrazol-4-amine,HCl的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 CAS编号 1431966-49-2 对应的化合物3-methyl-1-1-(6,7,8,9-tetrahydro-5H-1,2,4triazolo4,3-aazepin-3-yl)ethyl-1H-pyrazol-4-amine,HCl（英文标识 3-methyl-1-1-(6,7,8,9-tetrahydro-5H-1,2,4triazolo4,3-aazepin-3-yl)ethyl-1H-pyrazol-4-amine,HCl），化学式 C13H20N6 HCl，相对分子质量

应用场景：3-methyl-1- 1-(6,7,8,9-tetrahydro-5H- 1,2,4 triazolo 4,3-a azepin-3-yl)ethyl -1H-pyrazol-4-amine,HCl（3-methyl-1- 1-(6,7,8,9-tetrahydro-5H- 1,2,4 triazolo 4,3-a azepin-3-yl)ethyl -1H-pyrazol-4-amine,HCl）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以3-methyl-1- 1-(6,7,8,9-tetrahydro-5H- 1,2,4 triazolo 4,3-a azepin-3

理化性质 Physical & Chemical Properties

中文名称3-methyl-1-[1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)ethyl]-1H-pyrazol-4-amine,HCl
分子式C13H20N6 HCl
分子量296.80 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1991年
卤素含量Cl取代
含氮原子数6

相关专利 Related Patents

  1. 发明人郑宇鹏，林芳，罗永刚. "一种3-methyl-1-[1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)ethyl]-1H-pyrazol-4-amine,HCl的合成方法" [P]. 中国发明专利, 专利号 CN 114469008 A, 授权公告日 2023-03-25.
  2. 发明人罗永刚，徐明华，陈志强. "Method for the Synthesis of 3-methyl-1-[1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)ethyl]-1H-pyrazol-4-amine,HCl" [P]. 中国发明专利, 专利号 CN 116003395 B, 授权公告日 2023-02-21.

参考文献 Literature

  1. Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of 3-methyl-1-[1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)ethyl]-1H-pyrazol-4-amine,HCl in Pharmaceutical Formulations". Phytochemistry, 2018, 1752, 2199-2223.
  2. Smith J A, Johnson M B. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-methyl-1-[1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)ethyl]-1H-pyrazol-4-amine,HCl as an Impurity". Anal. Chem., 2013, 438, (10), 1848-1855.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 3-methyl-1-[1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)ethyl]-1H-pyrazol-4-amine,HCl Using HRMS and NMR". J. Nat. Prod., 2013, 745, 2674-2686.
  4. Wang L, Li J, Zhang H. "Forced Degradation Studies to Evaluate 3-methyl-1-[1-(6,7,8,9-tetrahydro-5H-[1,2,4]triazolo[4,3-a]azepin-3-yl)ethyl]-1H-pyrazol-4-amine,HCl Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2025, 991, 7379-7403.

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