4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid CAS 1439899-50-9
4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid
| CAS 号 | 1439899-50-9 |
| 分子式 | C12H15NO4 |
| 分子量 | 237.25 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
本产品为药物标准品4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid（4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid，CAS 1439899-50-9），分子式 C12H15NO4，分子量 237.25。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。
与同类药物标准品相比，4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid的分子量为237.25 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 1439899-50-9 对应的化合物4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid（英文标识 4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid），化学式 C12H15NO4，相对分子质量 237.25。 依据分子式为 C12H15NO4 的4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid结构特征，其分子内含氨基酸衍生物，酰胺类，含羟基，含醚键，这意味着该化合物在紫外光谱中会呈现特征性的吸收带。分子量 237.25 g/mol 这一参数对质谱检测中的分子离子峰识别具有直接参考价值。含氮官能团的存在使该化合物在ESI正离子模式下具有优良的离子化效率，适合LC-MS/MS分析。 本品适用于HPLC、GC、LC-MS/MS、GC-MS
应用场景：在化学分析实验室中，4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid（CAS 1439899-50-9）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇/乙腈（1:1）配制，于2-8°C冷藏保存，避光，密封防潮条
理化性质 Physical & Chemical Properties
| 中文名称 | 4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid |
| 分子式 | C12H15NO4 |
| 分子量 | 237.25 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于甲醇、乙腈、DMSO、水（微溶） |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 6.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1991年 |
| 含氮原子数 | 1 |
相关专利 Related Patents
- 发明人韩伟，马晓峰，陈志强. "一种4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 114739170 B, 授权公告日 2018-08-21.
- 发明人朱建伟，韩伟，林芳. "Method for the Synthesis of 4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 111700590 A, 授权公告日 2017-07-26.
参考文献 Literature
- Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of 4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid in Pharmaceutical Formulations". Molecules, 2024, 2109, 2023-2037.
- Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of 4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid as an Impurity". Phytochemistry, 2012, 2120, (5), 9753-9772.
- Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid Using HRMS and NMR". Anal. Methods, 2016, 798, 1993-2000.
- Wang L, Li J, Zhang H. "Forced Degradation Studies to Evaluate 4-(Oxan-4-ylmethoxy)pyridine-3-carboxylic acid Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2016, 2112, 3973-3978.
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