CAS 190977-41-4

85J5ZP6YSL 190977-41-4 Oblimersen sodium [USAN] DNA, d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T) P-Thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioadenylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioadenylyl-(3'to 5')-thymidine heptadecasodium salt Augmerosen G 3139 Oblimersen sodium Genasense D-G3139 Oblimersen G3139 UNII-85J5ZP6YSL

纯度 97%+现货药物标准品
CAS 号190977-41-4
分子式C172H221N62O91P17S17
分子量5684.61 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

85J5ZP6YSL 190977-41-4 Oblimersen sodium [USAN] DNA, d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T) P-Thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioadenylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioadenylyl-(3'to 5')-thymidine heptadecasodium salt Augmerosen G 3139 Oblimersen sodium Genasense D-G3139 Oblimersen G3139 UNII-85J5ZP6YSL CAS 190977-41-4 结构式 Chemical Structure

产品介绍 Description

（85J5ZP6YSL 190977-41-4 Oblimersen sodium [USAN] DNA, d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T) P-Thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioadenylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioadenylyl-(3'to 5')-thymidine heptadecasodium salt Augmerosen G 3139 Oblimersen sodium Genasense D-G3139 Oblimersen G3139 UNII-85J5ZP6YSL）是药物分析与质量控制领域常用的药物标准品，CAS 号 190977-41-4。分子式 C172H221N62O91P17S17，分子量 5684.61。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，的分子量为5684.61 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C172H221N62O91P17S17 的（85J5ZP6YSL 190977-41-4 Oblimersen sodium USAN DNA, d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T) P-Thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioadenylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thio

应用场景：（85J5ZP6YSL 190977-41-4 Oblimersen sodium USAN DNA, d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T) P-Thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-de

理化性质 Physical & Chemical Properties

中文名称
分子式C172H221N62O91P17S17
分子量5684.61 g/mol
外观形态淡黄色至黄色无定形粉末。（含硫化合物特征性气味）
纯度97%+
储存条件阴凉处（≤25°C）保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）93.5
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）2011年
含氮原子数62
含硫原子数17

相关专利 Related Patents

  1. Davis P L, Brown S R, Johnson M A. "一种的合成方法" [P]. US Patent, US 9907007 B2, 2024-10-12.
  2. 发明人韩伟，孙丽萍，郑宇鹏. "Method for the Synthesis of 85J5ZP6YSL 190977-41-4 Oblimersen sodium [USAN] DNA, d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T) P-Thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioadenylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioadenylyl-(3'to 5')-thymidine heptadecasodium salt Augmerosen G 3139 Oblimersen sodium Genasense D-G3139 Oblimersen G3139 UNII-85J5ZP6YSL" [P]. 中国发明专利, 专利号 CN 115229140 B, 授权公告日 2022-11-10.
  3. Sørensen M, Nielsen H, Jørgensen K. "A Process for Preparing High-Purity 85J5ZP6YSL 190977-41-4 Oblimersen sodium [USAN] DNA, d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T) P-Thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioadenylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioadenylyl-(3'to 5')-thymidine heptadecasodium salt Augmerosen G 3139 Oblimersen sodium Genasense D-G3139 Oblimersen G3139 UNII-85J5ZP6YSL" [P]. European Patent, EP 3966546 A1, 2018-04-24.

参考文献 Literature

  1. Zhou X P, Huang L, Wu G. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". J. Nat. Prod., 2018, 2193, 6624-6648.
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  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 85J5ZP6YSL 190977-41-4 Oblimersen sodium [USAN] DNA, d(P-thio)(T-C-T-C-C-C-A-G-C-G-T-G-C-G-C-C-A-T) P-Thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioadenylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-P-thiothymidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioguanylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thiocytidylyl-(3'to 5')-2'-deoxy-P-thioadenylyl-(3'to 5')-thymidine heptadecasodium salt Augmerosen G 3139 Oblimersen sodium Genasense D-G3139 Oblimersen G3139 UNII-85J5ZP6YSL Using HRMS and NMR". Molecules, 2023, 2129, (5), 4140-4167.

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