1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride CAS 1461705-08-7

1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride

纯度 97%+现货药物标准品
CAS 号1461705-08-7
分子式C14H20F2N2 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride 1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride CAS 1461705-08-7 结构式 Chemical Structure

产品介绍 Description

1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride（1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 1461705-08-7。分子式 C14H20F2N2 2*HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride的分子量为290.78 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride（1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride），CAS注册编号 1461705-08-7，化学分子式为 C14H20F2N2 2HCl，分子量 290.78 g/mol。 1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride（C14H20F2N2 2HCl）含有含氮杂环结构，含氰基，含氟/氯取代。卤素取代增加了化合物的密

应用场景：针对化学分析用途，1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride（1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride）是具有明确定量溯源的认证级对照品。 推荐以1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法

理化性质 Physical & Chemical Properties

中文名称1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride
分子式C14H20F2N2 2*HCl
分子量290.78 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1992年
卤素含量F/Cl取代
含氮原子数2

相关专利 Related Patents

  1. Kowalski A, Lefèvre J P, Johansson L. "一种1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride的合成方法" [P]. European Patent, EP 3205007 A1, 2016-06-06.
  2. Stevens L M, Davis P L, Chen K W. "Method for the Synthesis of 1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride" [P]. US Patent, US 11230879 B2, 2024-11-09.
  3. 发明人朱建伟，唐晓军，韩伟. "A Process for Preparing High-Purity 1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride" [P]. 中国发明专利, 专利号 CN 116311596 A, 授权公告日 2016-01-17.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2025, 2223, (11), 7063-7087.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride as an Impurity". Anal. Chem., 2013, 377, 7530-7536.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 1-(3,4-difluorophenyl)-2-methyl-2-(pyrrolidin-1-yl)propan-1-amine dihydrochloride Using HRMS and NMR". J. Sep. Sci., 2021, 1339, 4212-4242.

Related difluorophenyl Standards 同系列产品

推荐产品 Recommended Standards

为什么选择 CATO 佳途？

加载产品详情...