1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid CAS 1519828-13-7

1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1519828-13-7
分子式C14H13FN2O2
分子量260.26 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid CAS 1519828-13-7 结构式 Chemical Structure

产品介绍 Description

1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid（1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid，CAS 号 1519828-13-7）是 CATO 佳途自主生产的药物标准品，分子式 C14H13FN2O2，分子量 260.26。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopentacpyrazole-3-carboxylic acid在内的目标物的控制。 CAS编号 1519828-13-7 对应的化合物1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopentacpyrazole-3-carboxylic acid（英文标识 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopentacpyrazole-3-carboxylic acid），化学式 C14H13FN2O2，相对分子质量 260.26。 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopentacpyrazole-3-carboxylic acid（分子式 C14H13FN2O2）的化学结构中包含含氮杂环结构，酰胺类，含羟基，含醚键，含氟取代。在反相色谱体系中，其保留行为主要受其较高的疏水性（log

应用场景：针对化学分析用途，1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta c pyrazole-3-carboxylic acid（1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta c pyrazole-3-carboxylic acid）是具有明确定量溯源的认证级对照品。 推荐以1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta c pyrazole-3-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议

理化性质 Physical & Chemical Properties

中文名称1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid
分子式C14H13FN2O2
分子量260.26 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）9.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1992年
卤素含量F取代
含氮原子数2

相关专利 Related Patents

  1. 发明人王建平，杨光，马晓峰. "一种1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 113346645 B, 授权公告日 2015-10-06.
  2. Lee S K, Park J H, Patel M V. "Method for the Synthesis of 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid" [P]. US Patent, US 9547984 B2, 2021-05-19.
  3. 发明人郑宇鹏，沈红梅，陈志强. "A Process for Preparing High-Purity 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 109569066 A, 授权公告日 2024-09-26.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid in Pharmaceutical Formulations". Rapid Commun. Mass Spectrom., 2012, 2391, 7574-7591.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid as an Impurity". Biomed. Chromatogr., 2010, 118, (1), 8298-8309.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 1-(3-fluoro-5-methylphenyl)-1H,4H,5H,6H-cyclopenta[c]pyrazole-3-carboxylic acid Using HRMS and NMR". J. Sep. Sci., 2022, 1996, (5), 7490-7493.

Related fluoro Standards 同系列产品

推荐产品 Recommended Standards

为什么选择 CATO 佳途？

加载产品详情...