3-(3-methylphenyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid CAS 1536259-68-3
3-(3-methylphenyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid
| CAS 号 | 1536259-68-3 |
| 分子式 | C14H15N3O2 |
| 分子量 | 257.29 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
3-(3-methylphenyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid（3-(3-methylphenyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid）是药物分析与质量控制领域常用的药物标准品，CAS 号 1536259-68-3。分子式 C14H15N3O2，分子量 257.29。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。
作为认证标准物质（CRM），3-(3-methylphenyl)-5H,6H,7H,8H-1,2,4triazolo4,3-apyridine-6-carboxylic acid满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 化学式为 C14H15N3O2 的3-(3-methylphenyl)-5H,6H,7H,8H-1,2,4triazolo4,3-apyridine-6-carboxylic acid（3-(3-methylphenyl)-5H,6H,7H,8H-1,2,4triazolo4,3-apyridine-6-carboxylic acid），其CAS登记号是 1536259-68-3，分子量为 257.29 g/mol。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键的影响，3-(3-methylphenyl)-5H,6H,7H,8H-1,2,4triazolo4,3-apyridine-6
应用场景：在化学分析实验室中，3-(3-methylphenyl)-5H,6H,7H,8H- 1,2,4 triazolo 4,3-a pyridine-6-carboxylic acid（CAS 1536259-68-3）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以3-(3-methylphenyl)-5H,6H,7H,8H- 1,2,4 triazolo 4,3-a pyridine-6-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： -
理化性质 Physical & Chemical Properties
| 中文名称 | 3-(3-methylphenyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid |
| 分子式 | C14H15N3O2 |
| 分子量 | 257.29 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 9.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1992年 |
| 含氮原子数 | 3 |
相关专利 Related Patents
- Lefèvre J P, Rossi M, Jørgensen K. "一种3-(3-methylphenyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid的合成方法" [P]. European Patent, EP 3523224 A1, 2020-07-08.
- 发明人唐晓军，钱学锋，杨光. "Method for the Synthesis of 3-(3-methylphenyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid" [P]. 中国发明专利, 专利号 CN 114340738 A, 授权公告日 2021-03-22.
- Davis P L, Mueller T, Roberts E F. "A Process for Preparing High-Purity 3-(3-methylphenyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid" [P]. US Patent, US 10716786 B2, 2018-02-20.
参考文献 Literature
- Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 3-(3-methylphenyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid in Pharmaceutical Formulations". J. Chromatogr. A, 2011, 177, 6724-6733.
- Kumar A, Sharma P, Patel R S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-(3-methylphenyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid as an Impurity". Molecules, 2020, 1290, (4), 8727-8755.
- Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of 3-(3-methylphenyl)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyridine-6-carboxylic acid Using HRMS and NMR". Environ. Sci. Technol., 2021, 2186, (5), 8795-8810.
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