CAS 154934-97-1
154934-97-1 5-ethoxycarbonyl-4-(trifluoromethyl) -n pyrimidin-2-(1h)-one, tech. 5-ethoxycarbonyl-4-(trifluoromethyl)-1h-pyrimidin-2-one, tech 5-ethoxycarbonyl-4-(trifluoromethyl)-pyrimidin-2-(1h)-one tech 5-ethoxycarbonyl-4-(trifluoromethyl)pyrimidin-2(1h)-one Ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate ethyl 2-hydroxy-4-(trifluoromethyl)-5-pyrimidinecarboxylate ethyl 2-oxo-4-(trifluoromethyl)-1,2-dihydropyrimidine-5-carboxylate ethyl 2-oxo-4-(trifluoromethyl)-1,2-dihydropyrimidine-5-carboxylate, tech.
| CAS 号 | 154934-97-1 |
| 分子式 | C8H7F3N2O3 |
| 分子量 | 236.15 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
（英文名 154934-97-1 5-ethoxycarbonyl-4-(trifluoromethyl) -n pyrimidin-2-(1h)-one, tech. 5-ethoxycarbonyl-4-(trifluoromethyl)-1h-pyrimidin-2-one, tech 5-ethoxycarbonyl-4-(trifluoromethyl)-pyrimidin-2-(1h)-one tech 5-ethoxycarbonyl-4-(trifluoromethyl)pyrimidin-2(1h)-one Ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate ethyl 2-hydroxy-4-(trifluoromethyl)-5-pyrimidinecarboxylate ethyl 2-oxo-4-(trifluoromethyl)-1,2-dihydropyrimidine-5-carboxylate ethyl 2-oxo-4-(trifluoromethyl)-1,2-dihydropyrimidine-5-carboxylate, tech.，CAS 154934-97-1）属于药物标准品。分子式 C8H7F3N2O3，分子量 236.15。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括在内的目标物的控制。 （154934-97-1 5-ethoxycarbonyl-4-(trifluoromethyl) -n pyrimidin-2-(1h)-one, tech. 5-ethoxycarbonyl-4-(trifluoromethyl)-1h-pyrimidin-2-one, tech 5-ethoxycarbonyl-4-(trifluoromethyl)-pyrimidin-2-(1h)-one tech 5-ethoxycarbonyl-4-(trifluoromethyl)pyrimidin-2(1h)-one Ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate ethyl 2-hydroxy-4-(trifluoromethyl)-5-pyrimidinecarboxylate ethyl 2-oxo-4-(trifluoromethyl)-1,2-dihydropyrimidine-5-carboxylate ethyl 2-
应用场景：在化学分析实验室中，（CAS 154934-97-1）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； - 储备溶液建议用甲醇配制，于2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发条件下储存； - 低浓度工作液（<10 μg/mL）建议当天配制使用，不宜长期存放； - 开启安瓿瓶/西林瓶后应在干燥环境下尽快使用，防止吸潮影响称量准确性。
理化性质 Physical & Chemical Properties
| 中文名称 | |
| 分子式 | C8H7F3N2O3 |
| 分子量 | 236.15 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味，挥发性较低） |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发 |
| 溶解性参考 | 可溶于甲醇、乙醇、DMSO |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 5.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 2001年 |
| 卤素含量 | F取代 |
| 含氮原子数 | 2 |
相关专利 Related Patents
- 发明人刘建华，黄志刚，钱学锋. "一种的合成方法" [P]. 中国发明专利, 专利号 CN 116228789 A, 授权公告日 2019-07-14.
- 发明人朱建伟，赵玉洁，陈志强. "Method for the Synthesis of 154934-97-1 5-ethoxycarbonyl-4-(trifluoromethyl) -n pyrimidin-2-(1h)-one, tech. 5-ethoxycarbonyl-4-(trifluoromethyl)-1h-pyrimidin-2-one, tech 5-ethoxycarbonyl-4-(trifluoromethyl)-pyrimidin-2-(1h)-one tech 5-ethoxycarbonyl-4-(trifluoromethyl)pyrimidin-2(1h)-one Ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate ethyl 2-hydroxy-4-(trifluoromethyl)-5-pyrimidinecarboxylate ethyl 2-oxo-4-(trifluoromethyl)-1,2-dihydropyrimidine-5-carboxylate ethyl 2-oxo-4-(trifluoromethyl)-1,2-dihydropyrimidine-5-carboxylate, tech." [P]. 中国发明专利, 专利号 CN 113309345 B, 授权公告日 2018-01-03.
参考文献 Literature
- Kumar A, Sharma P, Patel R S. "Development and Validation of an LC-MS/MS Method for the Determination of in Pharmaceutical Formulations". Anal. Chim. Acta, 2016, 714, (12), 8716-8743.
- Yang F, Sun W, Liu J. "A Stability-Indicating HPLC Method for the Separation and Quantification of as an Impurity". Molecules, 2012, 905, 2837-2858.
- Chen X Y, Liu M, Zhao W Q. "Identification and Structural Characterization of a Novel Degradation Product of 154934-97-1 5-ethoxycarbonyl-4-(trifluoromethyl) -n pyrimidin-2-(1h)-one, tech. 5-ethoxycarbonyl-4-(trifluoromethyl)-1h-pyrimidin-2-one, tech 5-ethoxycarbonyl-4-(trifluoromethyl)-pyrimidin-2-(1h)-one tech 5-ethoxycarbonyl-4-(trifluoromethyl)pyrimidin-2(1h)-one Ethyl 2-hydroxy-4-(trifluoromethyl)pyrimidine-5-carboxylate ethyl 2-hydroxy-4-(trifluoromethyl)-5-pyrimidinecarboxylate ethyl 2-oxo-4-(trifluoromethyl)-1,2-dihydropyrimidine-5-carboxylate ethyl 2-oxo-4-(trifluoromethyl)-1,2-dihydropyrimidine-5-carboxylate, tech. Using HRMS and NMR". Anal. Methods, 2020, 2242, 4682-4697.
- Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2011, 691, (8), 3524-3547.
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