3-{[(tert-butoxy)carbonyl]amino}-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-3-carboxylic acid CAS 1589084-56-9
3-{[(tert-butoxy)carbonyl]amino}-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-3-carboxylic acid
| CAS 号 | 1589084-56-9 |
| 分子式 | C25H28N2O6 |
| 分子量 | 452.50 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
CAS 1589084-56-9 对应的3-{[(tert-butoxy)carbonyl]amino}-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-3-carboxylic acid（3-{[(tert-butoxy)carbonyl]amino}-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-3-carboxylic acid）为 CATO 佳途药物标准品产品线成员。分子式 C25H28N2O6，分子量 452.50。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。
本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 CAS编号 1589084-56-9 对应的化合物3-{(tert-butoxy)carbonylamino}-1-(9H-fluoren-9-ylmethoxy)carbonylpyrrolidine-3-carboxylic acid（英文标识 3-{(tert-butoxy)carbonylamino}-1-(9H-fluoren-9-ylmethoxy)carbonylpyrrolidine-3-carboxylic acid），化学式 C25H28N2O6，相对分子质量 452.50。 3-{(tert-butoxy)carbonylamino}-1-(9H-fluoren-9-ylmethoxy)carbonylpyrrolidine-3-carboxylic acid（分子式 C25H28N2O6）的化学结构中包含黄酮骨架，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能
应用场景：从实际应用出发，3-{ (tert-butoxy)carbonyl amino}-1- (9H-fluoren-9-ylmethoxy)carbonyl pyrrolidine-3-carboxylic acid（CAS 1589084-56-9）在化学分析中作为关键的基准对照物质。 推荐以3-{ (tert-butoxy)carbonyl amino}-1- (9H-fluoren-9-ylmethoxy)carbonyl pyrrolidine-3-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检
理化性质 Physical & Chemical Properties
| 中文名称 | 3-{[(tert-butoxy)carbonyl]amino}-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-3-carboxylic acid |
| 分子式 | C25H28N2O6 |
| 分子量 | 452.50 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 阴凉处（≤25°C）保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 13.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1993年 |
| 含氮原子数 | 2 |
相关专利 Related Patents
- 发明人朱建伟，陈志强，胡光. "一种3-{[(tert-butoxy)carbonyl]amino}-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-3-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 111469577 B, 授权公告日 2025-04-27.
- 发明人韩伟，黄志刚，王建平. "Method for the Synthesis of 3-{[(tert-butoxy)carbonyl]amino}-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 115726472 B, 授权公告日 2025-11-27.
- 发明人孙丽萍，赵玉洁，郑宇鹏. "A Process for Preparing High-Purity 3-{[(tert-butoxy)carbonyl]amino}-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 113260593 A, 授权公告日 2016-08-09.
参考文献 Literature
- Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of 3-{[(tert-butoxy)carbonyl]amino}-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-3-carboxylic acid in Pharmaceutical Formulations". Environ. Sci. Technol., 2015, 234, 3839-3843.
- Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of 3-{[(tert-butoxy)carbonyl]amino}-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-3-carboxylic acid as an Impurity". J. Chromatogr. A, 2014, 1432, (6), 2198-2213.
- Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of 3-{[(tert-butoxy)carbonyl]amino}-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-3-carboxylic acid Using HRMS and NMR". Food Chem., 2021, 1501, (10), 450-473.
- Smith J A, Johnson M B. "Forced Degradation Studies to Evaluate 3-{[(tert-butoxy)carbonyl]amino}-1-[(9H-fluoren-9-ylmethoxy)carbonyl]pyrrolidine-3-carboxylic acid Profile in Drug Substances According to ICH Guidelines". J. Nat. Prod., 2024, 1906, (7), 8842-8870.
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