tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate CAS 1707358-38-0

tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate

纯度 97%+现货药物标准品
CAS 号1707358-38-0
分子式C18H25F3N2O2
分子量358.40 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate CAS 1707358-38-0 结构式 Chemical Structure

产品介绍 Description

CAS 1707358-38-0 对应的tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate（tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate）为 CATO 佳途药物标准品产品线成员。分子式 C18H25F3N2O2，分子量 358.40。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

tert-Butyl {4-2-(trifluoromethyl)phenylpiperidin-4-yl}methylcarbamate的产生途径与其化学式中甾体骨架，酰胺类，含羟基，含醚键，含氟取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 1707358-38-0 对应的化合物tert-Butyl {4-2-(trifluoromethyl)phenylpiperidin-4-yl}methylcarbamate（英文标识 tert-Butyl {4-2-(trifluoromethyl)phenylpiperidin-4-yl}methylcarbamate），化学式 C18H25F3N2O2，相对分子质量 358.40。 受分子结构中甾体骨架，酰胺类，含羟基，含醚键，含氟取代的影响，tert-Butyl {4-2-(trifluoromethyl)phenylpiperidin-4-yl}methylcarbamate表现为类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）。其固体形态的物理化学属性——

应用场景：针对化学分析用途，tert-Butyl {4- 2-(trifluoromethyl)phenyl piperidin-4-yl}methylcarbamate（tert-Butyl {4- 2-(trifluoromethyl)phenyl piperidin-4-yl}methylcarbamate）是具有明确定量溯源的认证级对照品。 推荐以tert-Butyl {4- 2-(trifluoromethyl)phenyl piperidin-4-yl}methylcarbamate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据

理化性质 Physical & Chemical Properties

中文名称tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate
分子式C18H25F3N2O2
分子量358.40 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）6.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1994年
卤素含量F取代
含氮原子数2

相关专利 Related Patents

  1. Park J H, Chen K W, Patel M V. "一种tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate的合成方法" [P]. US Patent, US 11915752 B2, 2022-10-07.
  2. 发明人朱建伟，李文辉，赵玉洁. "Method for the Synthesis of tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate" [P]. 中国发明专利, 专利号 CN 111007380 B, 授权公告日 2016-04-04.
  3. Sørensen M, Jørgensen K, Johansson L. "A Process for Preparing High-Purity tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate" [P]. European Patent, EP 3908163 A1, 2018-12-19.

参考文献 Literature

  1. Xu M, Hu Y, Zhou D. "Development and Validation of an LC-MS/MS Method for the Determination of tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate in Pharmaceutical Formulations". Chromatographia, 2018, 827, (3), 5336-5340.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate as an Impurity". Anal. Methods, 2021, 96, (1), 375-393.
  3. Kowalski T, Nowak Z. "Identification and Structural Characterization of a Novel Degradation Product of tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate Using HRMS and NMR". Anal. Chem., 2017, 2027, (8), 2033-2063.
  4. Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate tert-Butyl {4-[2-(trifluoromethyl)phenyl]piperidin-4-yl}methylcarbamate Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2010, 154, 7674-7679.

推荐产品 Recommended Standards

为什么选择 CATO 佳途？

加载产品详情...