5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid CAS 1785259-05-3

5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1785259-05-3
分子式C10H16N2O5
分子量244.24 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid CAS 1785259-05-3 结构式 Chemical Structure

产品介绍 Description

5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid（5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid，CAS 号 1785259-05-3）是 CATO 佳途自主生产的药物标准品，分子式 C10H16N2O5，分子量 244.24。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

与同类药物标准品相比，5-({(tert-butoxy)carbonylamino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid的分子量为244.24 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 化学式为 C10H16N2O5 的5-({(tert-butoxy)carbonylamino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid（5-({(tert-butoxy)carbonylamino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid），其CAS登记号是 1785259-05-3，分子量为 244.24 g/mol。 受分子结构中氨基酸衍生物，酰胺类，含羟基，含醚键的影响，5-({(tert-butoxy)carbonylamino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid表现为类白色至淡黄色结晶性粉末。（具有氨/胺类

应用场景：针对化学分析用途，5-({ (tert-butoxy)carbonyl amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid（5-({ (tert-butoxy)carbonyl amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid）是具有明确定量溯源的认证级对照品。 推荐以5-({ (tert-butoxy)carbonyl amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现

理化性质 Physical & Chemical Properties

中文名称5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid
分子式C10H16N2O5
分子量244.24 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1994年
含氮原子数2

相关专利 Related Patents

  1. Thompson G K, Chen K W, Brown S R. "一种5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid的合成方法" [P]. US Patent, US 10623085 B2, 2018-02-02.
  2. 发明人赵玉洁，马晓峰，李文辉. "Method for the Synthesis of 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 116542881 A, 授权公告日 2017-03-23.
  3. 发明人钱学锋，朱建伟，张德明. "A Process for Preparing High-Purity 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 109394575 A, 授权公告日 2021-05-07.

参考文献 Literature

  1. Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid in Pharmaceutical Formulations". Phytochemistry, 2022, 1955, (1), 4238-4253.
  2. Martinez C, Lopez D R. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid as an Impurity". J. Pharm. Biomed. Anal., 2020, 2383, (2), 4491-4511.
  3. Mueller T, Schmidt R K. "Identification and Structural Characterization of a Novel Degradation Product of 5-({[(tert-butoxy)carbonyl]amino}methyl)-4,5-dihydro-1,2-oxazole-3-carboxylic acid Using HRMS and NMR". Chemosphere, 2017, 1254, 4758-4763.

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