{1-[(5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl]piperidin-3-yl}methanamine dihydrochloride CAS 1795434-18-2

{1-[(5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl]piperidin-3-yl}methanamine dihydrochloride

纯度 97%+现货药物标准品
CAS 号1795434-18-2
分子式C13H24N4O 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

{1-[(5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl]piperidin-3-yl}methanamine dihydrochloride {1-[(5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl]piperidin-3-yl}methanamine dihydrochloride CAS 1795434-18-2 结构式 Chemical Structure

产品介绍 Description

{1-[(5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl]piperidin-3-yl}methanamine dihydrochloride（{1-[(5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl]piperidin-3-yl}methanamine dihydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 1795434-18-2。分子式 C13H24N4O 2*HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 化学式为 C13H24N4O 2HCl 的{1-(5-tert-butyl-1,2,4-oxadiazol-3-yl)methylpiperidin-3-yl}methanamine dihydrochloride（{1-(5-tert-butyl-1,2,4-oxadiazol-3-yl)methylpiperidin-3-yl}methanamine dihydrochloride），其CAS登记号是 1795434-18-2，分子量为 288.82 g/mol。 受分子结构中酰胺类，含羟基，含醚键，含氯取代的影响，{1-(5-tert-butyl-1,2,4-oxadiazol-3-yl)methylpiperidin-3-yl}methanamine dihydrochloride表现为白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）。其固体形态的物理化学属性——包括288.82 g/mol的分子量——对于选择合适的样品前处理方法和

应用场景：在化学分析实验室中，{1- (5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl piperidin-3-yl}methanamine dihydrochloride（CAS 1795434-18-2）凭借其97%+的纯度做为基础物质，为定量分析提供基准参照。 推荐以{1- (5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl piperidin-3-yl}methanamine dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐

理化性质 Physical & Chemical Properties

中文名称{1-[(5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl]piperidin-3-yl}methanamine dihydrochloride
分子式C13H24N4O 2*HCl
分子量288.82 g/mol
外观形态白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1994年
卤素含量Cl取代
含氮原子数4

相关专利 Related Patents

  1. Kowalski A, Schröder R, Nowak P. "一种{1-[(5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl]piperidin-3-yl}methanamine dihydrochloride的合成方法" [P]. European Patent, EP 3253651 A1, 2018-10-19.
  2. 发明人陈志强，何建平，郭海燕. "Method for the Synthesis of {1-[(5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl]piperidin-3-yl}methanamine dihydrochloride" [P]. 中国发明专利, 专利号 CN 111541032 B, 授权公告日 2016-08-06.

参考文献 Literature

  1. Jensen P, Larsen A M, Olsen K. "Development and Validation of an LC-MS/MS Method for the Determination of {1-[(5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl]piperidin-3-yl}methanamine dihydrochloride in Pharmaceutical Formulations". Chromatographia, 2020, 1590, (1), 9965-9989.
  2. Zhou X P, Huang L, Wu G. "A Stability-Indicating HPLC Method for the Separation and Quantification of {1-[(5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl]piperidin-3-yl}methanamine dihydrochloride as an Impurity". J. Agric. Food Chem., 2013, 1029, 330-338.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of {1-[(5-tert-butyl-1,2,4-oxadiazol-3-yl)methyl]piperidin-3-yl}methanamine dihydrochloride Using HRMS and NMR". Rapid Commun. Mass Spectrom., 2019, 2333, (7), 7114-7130.

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