1-{[(tert-butoxy)carbonyl]amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid CAS 1796908-88-7

1-{[(tert-butoxy)carbonyl]amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1796908-88-7
分子式C14H25NO5
分子量287.35 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-{[(tert-butoxy)carbonyl]amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid 1-{[(tert-butoxy)carbonyl]amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid CAS 1796908-88-7 结构式 Chemical Structure

产品介绍 Description

1-{[(tert-butoxy)carbonyl]amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid（1-{[(tert-butoxy)carbonyl]amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid）是药物分析与质量控制领域常用的药物标准品，CAS 号 1796908-88-7。分子式 C14H25NO5，分子量 287.35。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，1-{(tert-butoxy)carbonylamino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid的分子量为287.35 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 1-{(tert-butoxy)carbonylamino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid（1-{(tert-butoxy)carbonylamino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid），CAS注册编号 1796908-88-7，化学分子式为 C14H25NO5，分子量 287.35 g/mol。 从化学结构特征来看，1-{(tert-butoxy)carbonylamino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid的分子骨架中包含酰胺类，羧酸类，含羟基，含醚键。该化合物的不饱和度为3.0，表

应用场景：针对化学分析用途，1-{ (tert-butoxy)carbonyl amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid（1-{ (tert-butoxy)carbonyl amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid）是具有明确定量溯源的认证级对照品。 推荐以1-{ (tert-butoxy)carbonyl amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid配制标准系列工作溶液，用于建立标准曲

理化性质 Physical & Chemical Properties

中文名称1-{[(tert-butoxy)carbonyl]amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid
分子式C14H25NO5
分子量287.35 g/mol
外观形态白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于甲醇、乙腈、DMSO、水（微溶）
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1994年
含氮原子数1

相关专利 Related Patents

  1. 发明人冯建国，郭海燕，胡光. "一种1-{[(tert-butoxy)carbonyl]amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid的合成方法" [P]. 中国发明专利, 专利号 CN 114832174 A, 授权公告日 2019-05-04.
  2. Mueller T C, Kowalski A, Nielsen H. "Method for the Synthesis of 1-{[(tert-butoxy)carbonyl]amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid" [P]. European Patent, EP 3802576 A1, 2017-12-07.

参考文献 Literature

  1. Wang L, Li J, Zhang H. "Development and Validation of an LC-MS/MS Method for the Determination of 1-{[(tert-butoxy)carbonyl]amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid in Pharmaceutical Formulations". J. Nat. Prod., 2022, 1461, (1), 4539-4567.
  2. Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-{[(tert-butoxy)carbonyl]amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid as an Impurity". Anal. Methods, 2014, 1195, (3), 441-445.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of 1-{[(tert-butoxy)carbonyl]amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid Using HRMS and NMR". Sci. Total Environ., 2011, 2104, (2), 1536-1549.
  4. Zhou X P, Huang L, Wu G. "Forced Degradation Studies to Evaluate 1-{[(tert-butoxy)carbonyl]amino}-3-ethoxy-2,2-dimethylcyclobutane-1-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Anal. Chim. Acta, 2022, 2101, (9), 4170-4184.

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