2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride CAS 1798745-74-0

2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride

纯度 97%+现货药物标准品
CAS 号1798745-74-0
分子式C12H19N3 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride 2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride CAS 1798745-74-0 结构式 Chemical Structure

产品介绍 Description

CAS 1798745-74-0 对应的2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride（2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride）为 CATO 佳途药物标准品产品线成员。分子式 C12H19N3 2*HCl。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride的产生途径与其化学式中含氮杂环结构，含氰基，含氯取代密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C12H19N3 2HCl 的2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride（2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride），其CAS登记号是 1798745-74-0，分子量为 241.76 g/mol。 2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride（C12H19N3 2HCl）含有含氮杂环结构，含氰基，含氯取代。卤素取代增

应用场景：2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride（2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride配制标准系列工作溶液，用于建立标准曲

理化性质 Physical & Chemical Properties

中文名称2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride
分子式C12H19N3 2*HCl
分子量241.76 g/mol
外观形态类白色至淡黄色低熔点固体。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1994年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人黄志刚，高志强，罗永刚. "一种2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 109130513 B, 授权公告日 2019-02-23.
  2. 发明人高志强，李文辉，罗永刚. "Method for the Synthesis of 2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride" [P]. 中国发明专利, 专利号 CN 115768633 A, 授权公告日 2019-02-24.
  3. 发明人何建平，唐晓军，钱学锋. "A Process for Preparing High-Purity 2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride" [P]. 中国发明专利, 专利号 CN 112973881 B, 授权公告日 2017-01-01.

参考文献 Literature

  1. Martinez C, Lopez D R. "Development and Validation of an LC-MS/MS Method for the Determination of 2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride in Pharmaceutical Formulations". Biomed. Chromatogr., 2014, 1557, (12), 6717-6735.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride as an Impurity". Molecules, 2014, 1771, (3), 261-281.
  3. O'Brien K, Kennedy M L. "Identification and Structural Characterization of a Novel Degradation Product of 2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride Using HRMS and NMR". J. Pharm. Biomed. Anal., 2020, 1890, 2315-2333.
  4. Chen X Y, Liu M, Zhao W Q. "Forced Degradation Studies to Evaluate 2-methyl-1-(pyrrolidin-3-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride Profile in Drug Substances According to ICH Guidelines". J. Agric. Food Chem., 2019, 2095, 5570-5586.

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