2-chloro-N-({4-[(3-methylpiperidin-1-yl)methyl]phenyl}methyl)acetamide hydrochloride CAS 1803586-23-3

2-chloro-N-({4-[(3-methylpiperidin-1-yl)methyl]phenyl}methyl)acetamide hydrochloride

纯度 97%+现货药物标准品
CAS 号1803586-23-3
分子式C16H23ClN2O HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-chloro-N-({4-[(3-methylpiperidin-1-yl)methyl]phenyl}methyl)acetamide hydrochloride 2-chloro-N-({4-[(3-methylpiperidin-1-yl)methyl]phenyl}methyl)acetamide hydrochloride CAS 1803586-23-3 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的2-chloro-N-({4-[(3-methylpiperidin-1-yl)methyl]phenyl}methyl)acetamide hydrochloride（2-chloro-N-({4-[(3-methylpiperidin-1-yl)methyl]phenyl}methyl)acetamide hydrochloride）为药物标准品，CAS 登记号 1803586-23-3，分子式 C16H23ClN2O HCl。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

作为认证标准物质（CRM），2-chloro-N-({4-(3-methylpiperidin-1-yl)methylphenyl}methyl)acetamide hydrochloride满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 化学式为 C16H23ClN2O HCl 的2-chloro-N-({4-(3-methylpiperidin-1-yl)methylphenyl}methyl)acetamide hydrochloride（2-chloro-N-({4-(3-methylpiperidin-1-yl)methylphenyl}methyl)acetamide hydrochloride），其CAS登记号是 1803586-23-3，分子量为 331.28 g/mol。 从化学结构特征来看，2-chloro-N-({4-(3-methylpiperidin-1-yl)methylphenyl}methyl)

应用场景：从实际应用出发，2-chloro-N-({4- (3-methylpiperidin-1-yl)methyl phenyl}methyl)acetamide hydrochloride（CAS 1803586-23-3）在化学分析中作为关键的基准对照物质。 推荐以2-chloro-N-({4- (3-methylpiperidin-1-yl)methyl phenyl}methyl)acetamide hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前

理化性质 Physical & Chemical Properties

中文名称2-chloro-N-({4-[(3-methylpiperidin-1-yl)methyl]phenyl}methyl)acetamide hydrochloride
分子式C16H23ClN2O HCl
分子量331.28 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人高志强，郭海燕，马晓峰. "一种2-chloro-N-({4-[(3-methylpiperidin-1-yl)methyl]phenyl}methyl)acetamide hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 117041536 B, 授权公告日 2020-10-25.
  2. 发明人高志强，黄志刚，陈志强. "Method for the Synthesis of 2-chloro-N-({4-[(3-methylpiperidin-1-yl)methyl]phenyl}methyl)acetamide hydrochloride" [P]. 中国发明专利, 专利号 CN 109935114 A, 授权公告日 2025-04-16.
  3. 发明人黄志刚，罗永刚，张德明. "A Process for Preparing High-Purity 2-chloro-N-({4-[(3-methylpiperidin-1-yl)methyl]phenyl}methyl)acetamide hydrochloride" [P]. 中国发明专利, 专利号 CN 117243176 A, 授权公告日 2023-10-13.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 2-chloro-N-({4-[(3-methylpiperidin-1-yl)methyl]phenyl}methyl)acetamide hydrochloride in Pharmaceutical Formulations". Environ. Sci. Technol., 2012, 1076, 3164-3176.
  2. Yamamoto K, Tanaka H, Suzuki T. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-chloro-N-({4-[(3-methylpiperidin-1-yl)methyl]phenyl}methyl)acetamide hydrochloride as an Impurity". Phytochemistry, 2021, 1960, (9), 8779-8794.
  3. Brown R C, Davis S M. "Identification and Structural Characterization of a Novel Degradation Product of 2-chloro-N-({4-[(3-methylpiperidin-1-yl)methyl]phenyl}methyl)acetamide hydrochloride Using HRMS and NMR". Anal. Chem., 2010, 347, (2), 5815-5830.
  4. Xu M, Hu Y, Zhou D. "Forced Degradation Studies to Evaluate 2-chloro-N-({4-[(3-methylpiperidin-1-yl)methyl]phenyl}methyl)acetamide hydrochloride Profile in Drug Substances According to ICH Guidelines". J. Sep. Sci., 2023, 281, 9687-9704.

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