2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride CAS 1803590-23-9

2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride

纯度 97%+现货药物标准品
CAS 号1803590-23-9
分子式C12H14Cl2N2O2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride 2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride CAS 1803590-23-9 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride（2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride，CAS 1803590-23-9），分子式 C12H14Cl2N2O2 HCl。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

作为认证标准物质（CRM），2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride（2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride），CAS注册编号 1803590-23-9，化学分子式为 C12H14Cl2N2O2 HCl，分子量 325.61 g/mol。 依据分子式为 C12H14Cl2N2O2 HCl 的2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride结构特征，其分子内含含氮杂环结构，酰胺类，含羟基，含醚键

应用场景：针对化学分析用途，2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride（2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride）是具有明确定量溯源的认证级对照品。 推荐以2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。

理化性质 Physical & Chemical Properties

中文名称2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride
分子式C12H14Cl2N2O2 HCl
分子量325.61 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，挥发性较低）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）5.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数2

相关专利 Related Patents

  1. 发明人冯建国，孙丽萍，马晓峰. "一种2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 115607861 A, 授权公告日 2020-11-11.
  2. Thompson G K, Fischer A B, Anderson J P. "Method for the Synthesis of 2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride" [P]. US Patent, US 11705939 B2, 2023-03-17.
  3. Johansson L, Kowalski A, Nowak P. "A Process for Preparing High-Purity 2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride" [P]. European Patent, EP 3846777 A1, 2016-11-19.

参考文献 Literature

  1. O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of 2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride in Pharmaceutical Formulations". Food Chem., 2017, 1632, (9), 1921-1928.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride as an Impurity". J. Sep. Sci., 2011, 2337, (1), 8667-8694.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride Using HRMS and NMR". J. Agric. Food Chem., 2011, 2464, 3530-3545.
  4. Fischer P, Wagner E. "Forced Degradation Studies to Evaluate 2-(2,4-dichlorophenoxy)-1-(piperazin-1-yl)ethan-1-one hydrochloride Profile in Drug Substances According to ICH Guidelines". J. Chromatogr. A, 2015, 232, (9), 1244-1255.

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