1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride CAS 1803590-76-2

1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride

纯度 97%+现货药物标准品
CAS 号1803590-76-2
分子式C12H19N3 2*HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride 1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride CAS 1803590-76-2 结构式 Chemical Structure

产品介绍 Description

1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride（1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride）是药物分析与质量控制领域常用的药物标准品，CAS 号 1803590-76-2。分子式 C12H19N3 2*HCl。纯度 97%+。CATO 佳途拥有 130,000+ 标准品现货目录，可一站式满足配套采购需求。

与同类药物标准品相比，1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride的分子量为241.76 g/mol这一特征使其在色谱分离条件和质谱检测参数设置上具有独特性。 CAS编号 1803590-76-2 对应的化合物1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride（英文标识 1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride），化学式 C12H19N3 2HCl，相对分子质量 241.76。 1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride（分子式 C12H19N3 2HCl）的化学结构中包含含氮杂环结构，含氰基，含氯

应用场景：从实际应用出发，1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride（CAS 1803590-76-2）在化学分析中作为关键的基准对照物质。 推荐以1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用乙腈为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡

理化性质 Physical & Chemical Properties

中文名称1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride
分子式C12H19N3 2*HCl
分子量241.76 g/mol
外观形态类白色至淡黄色低熔点固体。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）4.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数3

相关专利 Related Patents

  1. 发明人周伟，罗永刚，马晓峰. "一种1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 109726785 B, 授权公告日 2020-12-23.
  2. Williams B T, Thompson G K, Kumar R. "Method for the Synthesis of 1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride" [P]. US Patent, US 10323493 B2, 2019-10-17.
  3. Hughes D C, Patel M V, O'Brien P Q. "A Process for Preparing High-Purity 1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride" [P]. US Patent, US 11209190 B2, 2015-11-22.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of 1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride in Pharmaceutical Formulations". J. Pharm. Biomed. Anal., 2021, 1806, (9), 2754-2783.
  2. Wang L, Li J, Zhang H. "A Stability-Indicating HPLC Method for the Separation and Quantification of 1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride as an Impurity". Chromatographia, 2020, 1494, 7913-7939.
  3. Wang L, Li J, Zhang H. "Identification and Structural Characterization of a Novel Degradation Product of 1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride Using HRMS and NMR". Biomed. Chromatogr., 2015, 1849, 8644-8660.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 1-methyl-2-(pyrrolidin-2-yl)-4,5,6,7-tetrahydro-1H-1,3-benzodiazole dihydrochloride Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2011, 2285, (5), 1980-1983.

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