ethyl 5-{1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate CAS 1803591-47-0
ethyl 5-{1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate
| CAS 号 | 1803591-47-0 |
| 分子式 | C14H21N3O5 |
| 分子量 | 311.33 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
ethyl 5-{1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate（英文名 ethyl 5-{1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate，CAS 1803591-47-0）属于药物标准品。分子式 C14H21N3O5，分子量 311.33。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
ethyl 5-{1-(tert-butoxy)carbonylpyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 CAS编号 1803591-47-0 对应的化合物ethyl 5-{1-(tert-butoxy)carbonylpyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate（英文标识 ethyl 5-{1-(tert-butoxy)carbonylpyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate），化学式 C14H21N3O5，相对分子质量 311.33。 从化学结构特征来看，ethyl 5-{1-(tert-butoxy)carbonylpyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键。该化合物的不饱和度
应用场景：ethyl 5-{1- (tert-butoxy)carbonyl pyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate（ethyl 5-{1- (tert-butoxy)carbonyl pyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate，CAS 1803591-47-0）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以ethyl 5-{1- (tert-butoxy)carbonyl pyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate配制标准系列工作溶
理化性质 Physical & Chemical Properties
| 中文名称 | ethyl 5-{1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate |
| 分子式 | C14H21N3O5 |
| 分子量 | 311.33 g/mol |
| 外观形态 | 类白色至淡黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 6.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1995年 |
| 含氮原子数 | 3 |
相关专利 Related Patents
- 发明人林芳，刘建华，罗永刚. "一种ethyl 5-{1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 110081734 A, 授权公告日 2020-08-26.
- Fischer A B, Davis P L, Hughes D C. "Method for the Synthesis of ethyl 5-{1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate" [P]. US Patent, US 11754092 B2, 2020-06-13.
参考文献 Literature
- Kim S H, Park J Y. "Development and Validation of an LC-MS/MS Method for the Determination of ethyl 5-{1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate in Pharmaceutical Formulations". Biomed. Chromatogr., 2013, 1001, (4), 6691-6697.
- Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of ethyl 5-{1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate as an Impurity". Environ. Sci. Technol., 2015, 518, (12), 3485-3505.
- Jensen P, Larsen A M, Olsen K. "Identification and Structural Characterization of a Novel Degradation Product of ethyl 5-{1-[(tert-butoxy)carbonyl]pyrrolidin-2-yl}-1,2,4-oxadiazole-3-carboxylate Using HRMS and NMR". J. Agric. Food Chem., 2012, 2393, 1525-1546.
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