5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride CAS 1803593-65-8

5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride

纯度 97%+现货药物标准品
CAS 号1803593-65-8
分子式C14H12N4O2 HCl
分子量N/A g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride 5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride CAS 1803593-65-8 结构式 Chemical Structure

产品介绍 Description

5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride（5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride，CAS 号 1803593-65-8）是 CATO 佳途自主生产的药物标准品，分子式 C14H12N4O2 HCl。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。

作为认证标准物质（CRM），5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride（5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride），CAS注册编号 1803593-65-8，化学分子式为 C14H12N4O2 HCl，分子量 304.73 g/mol。 5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochlor

应用场景：5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride（5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride，CAS 1803593-65-8）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride配制标准系列

理化性质 Physical & Chemical Properties

中文名称5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride
分子式C14H12N4O2 HCl
分子量304.73 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Cl取代
含氮原子数4

相关专利 Related Patents

  1. 发明人徐明华，马晓峰，朱建伟. "一种5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride的合成方法" [P]. 中国发明专利, 专利号 CN 111049033 B, 授权公告日 2018-03-13.
  2. Klinger H, Johnson M A, Williams B T. "Method for the Synthesis of 5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride" [P]. US Patent, US 10859964 B2, 2016-02-07.
  3. O'Brien P Q, Stevens L M, Yamamoto T. "A Process for Preparing High-Purity 5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride" [P]. US Patent, US 9293559 B2, 2023-10-20.

参考文献 Literature

  1. Zhang Y, Li Q, Chen T. "Development and Validation of an LC-MS/MS Method for the Determination of 5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride in Pharmaceutical Formulations". J. Agric. Food Chem., 2023, 1700, (9), 8967-8987.
  2. Brown R C, Davis S M. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride as an Impurity". Anal. Methods, 2019, 1371, (8), 3660-3668.
  3. Lee J H, Choi Y S. "Identification and Structural Characterization of a Novel Degradation Product of 5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride Using HRMS and NMR". Chemosphere, 2019, 1737, (2), 1970-1987.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 5-methyl-1-(quinolin-6-ylmethyl)-1H-1,2,3-triazole-4-carboxylic acid hydrochloride Profile in Drug Substances According to ICH Guidelines". Biomed. Chromatogr., 2018, 399, 969-988.

Related methyl Standards 同系列产品

推荐产品 Recommended Standards

为什么选择 CATO 佳途？

加载产品详情...