5-[(pyridin-3-ylformamido)methyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxylic acid CAS 1803596-92-0
5-[(pyridin-3-ylformamido)methyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxylic acid
| CAS 号 | 1803596-92-0 |
| 分子式 | C15H16N4O3 |
| 分子量 | 300.31 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
5-[(pyridin-3-ylformamido)methyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxylic acid（英文名 5-[(pyridin-3-ylformamido)methyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxylic acid，CAS 1803596-92-0）属于药物标准品。分子式 C15H16N4O3，分子量 300.31。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。
在质量保证方面，5-(pyridin-3-ylformamido)methyl-4H,5H,6H,7H-pyrazolo1,5-apyridine-3-carboxylic acid的生产和定值严格遵循ISO 17034:2016（认证标准物质生产者）的要求。纯度定值采用质量平衡法和定量核磁共振（qNMR）等多种正交方法进行交叉验证，扩展不确定度报告为95%置信水平（k=2）。每个批次的均匀性和稳定性均经过独立的统计评估。 5-(pyridin-3-ylformamido)methyl-4H,5H,6H,7H-pyrazolo1,5-apyridine-3-carboxylic acid（5-(pyridin-3-ylformamido)methyl-4H,5H,6H,7H-pyrazolo1,5-apyridine-3-carboxylic acid），CAS注册编号 1803596-92-0，化学分子式为 C15H16N4O3，分子量 300.31 g/mol。 依据分子式为 C15H16N4O3 的5-(pyridin-3-y
应用场景：5- (pyridin-3-ylformamido)methyl -4H,5H,6H,7H-pyrazolo 1,5-a pyridine-3-carboxylic acid（5- (pyridin-3-ylformamido)methyl -4H,5H,6H,7H-pyrazolo 1,5-a pyridine-3-carboxylic acid，CAS 1803596-92-0）的标准化应用场景涵盖化学分析等多个专业技术领域。 推荐以5- (pyridin-3-ylformamido)methyl -4H,5H,6H,7H-pyrazolo 1,5-a pyridine-3-carbox
理化性质 Physical & Chemical Properties
| 中文名称 | 5-[(pyridin-3-ylformamido)methyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxylic acid |
| 分子式 | C15H16N4O3 |
| 分子量 | 300.31 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 10.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1995年 |
| 含氮原子数 | 4 |
相关专利 Related Patents
- Björnsson E, Martínez F, Johansson L. "一种5-[(pyridin-3-ylformamido)methyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxylic acid的合成方法" [P]. European Patent, EP 3222921 A1, 2020-08-05.
- 发明人冯建国，唐晓军，罗永刚. "Method for the Synthesis of 5-[(pyridin-3-ylformamido)methyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxylic acid" [P]. 中国发明专利, 专利号 CN 114149706 B, 授权公告日 2016-08-17.
参考文献 Literature
- Garcia M, Rodriguez P. "Development and Validation of an LC-MS/MS Method for the Determination of 5-[(pyridin-3-ylformamido)methyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxylic acid in Pharmaceutical Formulations". Talanta, 2014, 316, (9), 8464-8471.
- O'Brien K, Kennedy M L. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-[(pyridin-3-ylformamido)methyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxylic acid as an Impurity". Anal. Chim. Acta, 2014, 1839, 8664-8677.
- Fischer P, Wagner E. "Identification and Structural Characterization of a Novel Degradation Product of 5-[(pyridin-3-ylformamido)methyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxylic acid Using HRMS and NMR". Biomed. Chromatogr., 2023, 2412, (10), 8887-8908.
- Mueller T, Schmidt R K. "Forced Degradation Studies to Evaluate 5-[(pyridin-3-ylformamido)methyl]-4H,5H,6H,7H-pyrazolo[1,5-a]pyridine-3-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Rapid Commun. Mass Spectrom., 2021, 1224, (7), 8211-8215.
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