methyl 2-methyl-7-oxabicyclo[2.2.1]heptane-2-carboxylate CAS 1803604-88-7

methyl 2-methyl-7-oxabicyclo[2.2.1]heptane-2-carboxylate

纯度 97%+现货药物标准品
CAS 号1803604-88-7
分子式C9H14O3
分子量170.21 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

methyl 2-methyl-7-oxabicyclo[2.2.1]heptane-2-carboxylate methyl 2-methyl-7-oxabicyclo[2.2.1]heptane-2-carboxylate CAS 1803604-88-7 结构式 Chemical Structure

产品介绍 Description

CAS 1803604-88-7 对应的methyl 2-methyl-7-oxabicyclo[2.2.1]heptane-2-carboxylate（methyl 2-methyl-7-oxabicyclo[2.2.1]heptane-2-carboxylate）为 CATO 佳途药物标准品产品线成员。分子式 C9H14O3，分子量 170.21。纯度 97%+。所有批次均经 HPLC/NMR 等多项检测确认，质量稳定可溯源。

在现行药典和法规框架下，药物标准品的合规要求中明确涉及对包括methyl 2-methyl-7-oxabicyclo2.2.1heptane-2-carboxylate在内的目标物的控制。 化学式为 C9H14O3 的methyl 2-methyl-7-oxabicyclo2.2.1heptane-2-carboxylate（methyl 2-methyl-7-oxabicyclo2.2.1heptane-2-carboxylate），其CAS登记号是 1803604-88-7，分子量为 170.21 g/mol。 受分子结构中羧酸类，含羟基，含醚键的影响，methyl 2-methyl-7-oxabicyclo2.2.1heptane-2-carboxylate表现为白色至类白色结晶性粉末。其固体形态的物理化学属性——包括170.21 g/mol的分子量——对于选择合适的样品前处理方法和分析技术具有指导意义。由于结构中存在共轭发色团，该化合物在200-400 nm区间具有显著的紫外吸收，便于HPLC-UV检测。 推荐用于分析方法开发与验证，产品提供完整C

应用场景：针对化学分析用途，methyl 2-methyl-7-oxabicyclo 2.2.1 heptane-2-carboxylate（methyl 2-methyl-7-oxabicyclo 2.2.1 heptane-2-carboxylate）是具有明确定量溯源的认证级对照品。 推荐以methyl 2-methyl-7-oxabicyclo 2.2.1 heptane-2-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇为溶剂配制储备溶液，根据检测灵敏度需求逐级稀释。 使用建议： - 称量前将样品在干燥器内平衡至室温（约30分钟）； -

理化性质 Physical & Chemical Properties

中文名称methyl 2-methyl-7-oxabicyclo[2.2.1]heptane-2-carboxylate
分子式C9H14O3
分子量170.21 g/mol
外观形态白色至类白色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，密封防潮
溶解性参考可溶于甲醇、乙醇、DMSO
稳定性空气中长期暴露可能发生缓慢氧化；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）3.0
UV特征有紫外吸收
CAS登记年份（估）1995年

相关专利 Related Patents

  1. 发明人高志强，杨光，王建平. "一种methyl 2-methyl-7-oxabicyclo[2.2.1]heptane-2-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 111742188 A, 授权公告日 2020-11-06.
  2. Roberts E F, Davis P L, Park J H. "Method for the Synthesis of methyl 2-methyl-7-oxabicyclo[2.2.1]heptane-2-carboxylate" [P]. US Patent, US 9170273 B2, 2019-11-27.
  3. 发明人高志强，林芳，张德明. "A Process for Preparing High-Purity methyl 2-methyl-7-oxabicyclo[2.2.1]heptane-2-carboxylate" [P]. 中国发明专利, 专利号 CN 114414895 A, 授权公告日 2024-08-20.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of methyl 2-methyl-7-oxabicyclo[2.2.1]heptane-2-carboxylate in Pharmaceutical Formulations". J. Chromatogr. A, 2013, 1051, 8928-8950.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl 2-methyl-7-oxabicyclo[2.2.1]heptane-2-carboxylate as an Impurity". Talanta, 2010, 1260, (12), 236-261.
  3. Hughes D, Roberts J, Thomas A. "Identification and Structural Characterization of a Novel Degradation Product of methyl 2-methyl-7-oxabicyclo[2.2.1]heptane-2-carboxylate Using HRMS and NMR". Chromatographia, 2020, 154, 4627-4640.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate methyl 2-methyl-7-oxabicyclo[2.2.1]heptane-2-carboxylate Profile in Drug Substances According to ICH Guidelines". Sci. Total Environ., 2014, 2259, 2418-2426.

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