methyl 1-[(4-ethylphenyl)methyl]-5-methyl-1H-1,2,3-triazole-4-carboxylate CAS 1803605-03-9
methyl 1-[(4-ethylphenyl)methyl]-5-methyl-1H-1,2,3-triazole-4-carboxylate
| CAS 号 | 1803605-03-9 |
| 分子式 | C14H17N3O2 |
| 分子量 | 259.30 g/mol |
| 分类 | 药物标准品 / 原料药标准品 |
| 库存状态 | 现货 |
化学结构式 Structure
产品介绍 Description
methyl 1-[(4-ethylphenyl)methyl]-5-methyl-1H-1,2,3-triazole-4-carboxylate（methyl 1-[(4-ethylphenyl)methyl]-5-methyl-1H-1,2,3-triazole-4-carboxylate，CAS 号 1803605-03-9）是 CATO 佳途自主生产的药物标准品，分子式 C14H17N3O2，分子量 259.30。纯度 97%+。本品采用严格的质量控制体系生产，附 COA 证书，适用于药物研发、质量控制和法规申报等场景。
methyl 1-(4-ethylphenyl)methyl-5-methyl-1H-1,2,3-triazole-4-carboxylate的产生途径与其化学式中含氮杂环结构，酰胺类，含羟基，含醚键密切相关，该结构特征决定了其在合成/纯化或降解过程中出现的概率与行为。 化学式为 C14H17N3O2 的methyl 1-(4-ethylphenyl)methyl-5-methyl-1H-1,2,3-triazole-4-carboxylate（methyl 1-(4-ethylphenyl)methyl-5-methyl-1H-1,2,3-triazole-4-carboxylate），其CAS登记号是 1803605-03-9，分子量为 259.30 g/mol。 methyl 1-(4-ethylphenyl)methyl-5-methyl-1H-1,2,3-triazole-4-carboxylate（分子式 C14H17N3O2）的化学结构中包含含氮杂环结构，酰胺类，含羟基，含醚键。在反相色谱体系中，其保留行为主要受含氮官能团的质子化状态影响，这为HPLC
应用场景：methyl 1- (4-ethylphenyl)methyl -5-methyl-1H-1,2,3-triazole-4-carboxylate（methyl 1- (4-ethylphenyl)methyl -5-methyl-1H-1,2,3-triazole-4-carboxylate）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以methyl 1- (4-ethylphenyl)methyl -5-methyl-1H-1,2,3-triazole-4-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂配制储
理化性质 Physical & Chemical Properties
| 中文名称 | methyl 1-[(4-ethylphenyl)methyl]-5-methyl-1H-1,2,3-triazole-4-carboxylate |
| 分子式 | C14H17N3O2 |
| 分子量 | 259.30 g/mol |
| 外观形态 | 淡黄色至黄色结晶性粉末 |
| 纯度 | 97%+ |
| 储存条件 | 2-8°C冷藏保存，避光，密封防潮 |
| 溶解性参考 | 可溶于DMSO、DMF、甲醇 |
| 稳定性 | 空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封 |
| 化合物类型 | 药物标准品 |
| 子类 | 原料药标准品 |
| 不饱和度（DBE） | 8.0 |
| UV特征 | 有紫外吸收 |
| 结构特征 | 含芳环 |
| CAS登记年份（估） | 1995年 |
| 含氮原子数 | 3 |
相关专利 Related Patents
- 发明人杨光，郑宇鹏，罗永刚. "一种methyl 1-[(4-ethylphenyl)methyl]-5-methyl-1H-1,2,3-triazole-4-carboxylate的合成方法" [P]. 中国发明专利, 专利号 CN 108027482 A, 授权公告日 2021-06-06.
- 发明人胡光，徐明华，马晓峰. "Method for the Synthesis of methyl 1-[(4-ethylphenyl)methyl]-5-methyl-1H-1,2,3-triazole-4-carboxylate" [P]. 中国发明专利, 专利号 CN 114059404 B, 授权公告日 2019-02-13.
参考文献 Literature
- O'Brien K, Kennedy M L. "Development and Validation of an LC-MS/MS Method for the Determination of methyl 1-[(4-ethylphenyl)methyl]-5-methyl-1H-1,2,3-triazole-4-carboxylate in Pharmaceutical Formulations". Phytochemistry, 2023, 962, 1644-1671.
- Kowalski T, Nowak Z. "A Stability-Indicating HPLC Method for the Separation and Quantification of methyl 1-[(4-ethylphenyl)methyl]-5-methyl-1H-1,2,3-triazole-4-carboxylate as an Impurity". Anal. Chim. Acta, 2021, 469, (1), 2664-2677.
- Garcia M, Rodriguez P. "Identification and Structural Characterization of a Novel Degradation Product of methyl 1-[(4-ethylphenyl)methyl]-5-methyl-1H-1,2,3-triazole-4-carboxylate Using HRMS and NMR". Biomed. Chromatogr., 2011, 2068, 3347-3370.
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