2-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-1-methyl-5-oxopyrrolidine-3-carboxylic acid CAS 1803605-63-1

2-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-1-methyl-5-oxopyrrolidine-3-carboxylic acid

纯度 97%+现货药物标准品
CAS 号1803605-63-1
分子式C15H14FN3O3
分子量303.29 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

2-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-1-methyl-5-oxopyrrolidine-3-carboxylic acid 2-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-1-methyl-5-oxopyrrolidine-3-carboxylic acid CAS 1803605-63-1 结构式 Chemical Structure

产品介绍 Description

本产品为药物标准品2-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-1-methyl-5-oxopyrrolidine-3-carboxylic acid（2-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-1-methyl-5-oxopyrrolidine-3-carboxylic acid，CAS 1803605-63-1），分子式 C15H14FN3O3，分子量 303.29。纯度 97%+。适用于分析方法开发、方法验证及日常质检，CATO 提供全程冷链与全球配送。

作为认证标准物质（CRM），2-1-(4-fluorophenyl)-1H-pyrazol-4-yl-1-methyl-5-oxopyrrolidine-3-carboxylic acid满足CNAS-CL04（ISO/IEC 17025）对标准物质的计量溯源性要求。批间一致性通过控制图（Control Chart）进行持续监控，保证不同批次间量值的一致性。 化学式为 C15H14FN3O3 的2-1-(4-fluorophenyl)-1H-pyrazol-4-yl-1-methyl-5-oxopyrrolidine-3-carboxylic acid（2-1-(4-fluorophenyl)-1H-pyrazol-4-yl-1-methyl-5-oxopyrrolidine-3-carboxylic acid），其CAS登记号是 1803605-63-1，分子量为 303.29 g/mol。 2-1-(4-fluorophenyl)-1H-pyrazol-4-yl-1-methyl-5-oxopyrrolidine-3-carboxylic aci

应用场景：针对化学分析用途，2- 1-(4-fluorophenyl)-1H-pyrazol-4-yl -1-methyl-5-oxopyrrolidine-3-carboxylic acid（2- 1-(4-fluorophenyl)-1H-pyrazol-4-yl -1-methyl-5-oxopyrrolidine-3-carboxylic acid）是具有明确定量溯源的认证级对照品。 推荐以2- 1-(4-fluorophenyl)-1H-pyrazol-4-yl -1-methyl-5-oxopyrrolidine-3-carboxylic acid配制标准系列工作溶液，用于建立标准曲线实现

理化性质 Physical & Chemical Properties

中文名称2-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-1-methyl-5-oxopyrrolidine-3-carboxylic acid
分子式C15H14FN3O3
分子量303.29 g/mol
外观形态淡黄色至黄色结晶性粉末。（具有轻微卤代物特征气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）10.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量F取代
含氮原子数3

相关专利 Related Patents

  1. Jørgensen K, Nowak P, Kowalski A. "一种2-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-1-methyl-5-oxopyrrolidine-3-carboxylic acid的合成方法" [P]. European Patent, EP 3686701 A1, 2020-05-01.
  2. Lefèvre J P, Jørgensen K, Mueller T C. "Method for the Synthesis of 2-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-1-methyl-5-oxopyrrolidine-3-carboxylic acid" [P]. European Patent, EP 3570827 A1, 2024-03-15.
  3. Williams B T, Yamamoto T, Park J H. "A Process for Preparing High-Purity 2-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-1-methyl-5-oxopyrrolidine-3-carboxylic acid" [P]. US Patent, US 9514582 B2, 2024-12-22.

参考文献 Literature

  1. Yang F, Sun W, Liu J. "Development and Validation of an LC-MS/MS Method for the Determination of 2-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-1-methyl-5-oxopyrrolidine-3-carboxylic acid in Pharmaceutical Formulations". Food Chem., 2025, 1935, (7), 8822-8848.
  2. Lee J H, Choi Y S. "A Stability-Indicating HPLC Method for the Separation and Quantification of 2-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-1-methyl-5-oxopyrrolidine-3-carboxylic acid as an Impurity". J. Agric. Food Chem., 2025, 1362, (5), 540-544.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of 2-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-1-methyl-5-oxopyrrolidine-3-carboxylic acid Using HRMS and NMR". J. Pharm. Biomed. Anal., 2010, 93, 8489-8509.
  4. Jensen P, Larsen A M, Olsen K. "Forced Degradation Studies to Evaluate 2-[1-(4-fluorophenyl)-1H-pyrazol-4-yl]-1-methyl-5-oxopyrrolidine-3-carboxylic acid Profile in Drug Substances According to ICH Guidelines". Anal. Chem., 2022, 2111, 4507-4512.

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