5-bromo-1-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-2-methyl-1,4-dihydropyrimidin-4-one CAS 1803609-58-6

5-bromo-1-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-2-methyl-1,4-dihydropyrimidin-4-one

纯度 97%+现货药物标准品
CAS 号1803609-58-6
分子式C10H11BrN4O2
分子量299.12 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

5-bromo-1-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-2-methyl-1,4-dihydropyrimidin-4-one 5-bromo-1-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-2-methyl-1,4-dihydropyrimidin-4-one CAS 1803609-58-6 结构式 Chemical Structure

产品介绍 Description

5-bromo-1-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-2-methyl-1,4-dihydropyrimidin-4-one（英文名 5-bromo-1-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-2-methyl-1,4-dihydropyrimidin-4-one，CAS 1803609-58-6）属于药物标准品。分子式 C10H11BrN4O2，分子量 299.12。纯度 97%+。佳途科技作为 ISO 17034 认可的标准物质生产商，为该产品提供完整的质量文件与技术支持。

在定量分析中，可作为校准标准或内标物使用，适用于多种检测技术平台（UV-Vis, FLD, MS, FID）。 5-bromo-1-(5-ethyl-1,2,4-oxadiazol-3-yl)methyl-2-methyl-1,4-dihydropyrimidin-4-one（5-bromo-1-(5-ethyl-1,2,4-oxadiazol-3-yl)methyl-2-methyl-1,4-dihydropyrimidin-4-one），CAS注册编号 1803609-58-6，化学分子式为 C10H11BrN4O2，分子量 299.12 g/mol。 受分子结构中含氮杂环结构，酰胺类，含羟基，含醚键，含溴取代的影响，5-bromo-1-(5-ethyl-1,2,4-oxadiazol-3-yl)methyl-2-methyl-1,4-dihydropyrimidin-4-one表现为类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）。其固体形态的物理化学属性——包括299.12 g/mol的分子量——对于选择合适的样品前处理

应用场景：5-bromo-1- (5-ethyl-1,2,4-oxadiazol-3-yl)methyl -2-methyl-1,4-dihydropyrimidin-4-one（5-bromo-1- (5-ethyl-1,2,4-oxadiazol-3-yl)methyl -2-methyl-1,4-dihydropyrimidin-4-one）作为药物标准品，在化学分析分析领域承担着重要的角色。 推荐以5-bromo-1- (5-ethyl-1,2,4-oxadiazol-3-yl)methyl -2-methyl-1,4-dihydropyrimidin-4-one配制标准系列工作溶液，用于建立

理化性质 Physical & Chemical Properties

中文名称5-bromo-1-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-2-methyl-1,4-dihydropyrimidin-4-one
分子式C10H11BrN4O2
分子量299.12 g/mol
外观形态类白色至淡黄色结晶性粉末。（具有轻微卤代物特征气味，具有氨/胺类微弱气味）
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮，密闭保存防止挥发
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封；含酯键，遇强碱易水解
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
卤素含量Br取代
含氮原子数4

相关专利 Related Patents

  1. 发明人沈红梅，赵玉洁，马晓峰. "一种5-bromo-1-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-2-methyl-1,4-dihydropyrimidin-4-one的合成方法" [P]. 中国发明专利, 专利号 CN 111995105 A, 授权公告日 2020-07-23.
  2. Lefèvre J P, Björnsson E, Schröder R. "Method for the Synthesis of 5-bromo-1-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-2-methyl-1,4-dihydropyrimidin-4-one" [P]. European Patent, EP 3360271 A1, 2022-04-27.

参考文献 Literature

  1. Fischer P, Wagner E. "Development and Validation of an LC-MS/MS Method for the Determination of 5-bromo-1-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-2-methyl-1,4-dihydropyrimidin-4-one in Pharmaceutical Formulations". J. Sep. Sci., 2021, 717, (9), 7732-7735.
  2. Jensen P, Larsen A M, Olsen K. "A Stability-Indicating HPLC Method for the Separation and Quantification of 5-bromo-1-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-2-methyl-1,4-dihydropyrimidin-4-one as an Impurity". Sci. Total Environ., 2013, 1777, (6), 1174-1191.
  3. Zhou X P, Huang L, Wu G. "Identification and Structural Characterization of a Novel Degradation Product of 5-bromo-1-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-2-methyl-1,4-dihydropyrimidin-4-one Using HRMS and NMR". J. Nat. Prod., 2025, 1000, 2967-2981.
  4. Zhang Y, Li Q, Chen T. "Forced Degradation Studies to Evaluate 5-bromo-1-[(5-ethyl-1,2,4-oxadiazol-3-yl)methyl]-2-methyl-1,4-dihydropyrimidin-4-one Profile in Drug Substances According to ICH Guidelines". Anal. Methods, 2017, 1059, 4201-4224.

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