rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate CAS 1909286-43-6

rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate

纯度 97%+现货药物标准品
CAS 号1909286-43-6
分子式C13H16N2O3
分子量248.28 g/mol
分类药物标准品 / 原料药标准品
库存状态现货

化学结构式 Structure

rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate CAS 1909286-43-6 结构式 Chemical Structure

产品介绍 Description

CATO 佳途供应的rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate（rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate）为药物标准品，CAS 登记号 1909286-43-6，分子式 C13H16N2O3，分子量 248.28。纯度 97%+。产品现货库存充足，可提供定制化规格与批次追踪服务。

本品适用于HPLC、GC、LC-MS/MS、GC-MS等主要色谱平台的定量分析，可作为外标法校准标准品或系统适用性测试参考物质使用。 CAS编号 1909286-43-6 对应的化合物rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate（英文标识 rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate），化学式 C13H16N2O3，相对分子质量 248.28。 从化学结构特征来看，rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate的分子骨架中包含含氮杂环结构，酰胺类，含羟基，含醚键。该化合物的不饱和度为7.0，表明结构中存在约7个环或双键等价单元。分子量为248.28 g/mol，属于中等分子量化合物。分子中包含芳环或共轭体系，在UV-Vis光谱中具有特征性吸收带，适用于紫

应用场景：针对化学分析用途，rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate（rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate）是具有明确定量溯源的认证级对照品。 推荐以rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate配制标准系列工作溶液，用于建立标准曲线实现外标法定量。 建议使用甲醇/乙腈（1:1）为溶剂

理化性质 Physical & Chemical Properties

中文名称rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate
分子式C13H16N2O3
分子量248.28 g/mol
外观形态类白色至淡黄色结晶性粉末
纯度97%+
储存条件2-8°C冷藏保存，避光，密封防潮
溶解性参考可溶于DMSO、DMF、甲醇
稳定性空气中长期暴露可能发生缓慢氧化；对光敏感，应避免强光直射；具有吸湿性，开封后应立即密封
化合物类型药物标准品
子类原料药标准品
不饱和度（DBE）7.0
UV特征有紫外吸收
结构特征含芳环
CAS登记年份（估）1995年
含氮原子数2

相关专利 Related Patents

  1. Lefèvre J P, Kowalski A, Schröder R. "一种rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate的合成方法" [P]. European Patent, EP 3057389 A1, 2025-04-08.
  2. 发明人杨光，韩伟，唐晓军. "Method for the Synthesis of rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate" [P]. 中国发明专利, 专利号 CN 115984873 A, 授权公告日 2021-11-27.

参考文献 Literature

  1. Hughes D, Roberts J, Thomas A. "Development and Validation of an LC-MS/MS Method for the Determination of rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate in Pharmaceutical Formulations". Molecules, 2010, 1007, (5), 1845-1859.
  2. Chen X Y, Liu M, Zhao W Q. "A Stability-Indicating HPLC Method for the Separation and Quantification of rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate as an Impurity". J. Chromatogr. A, 2017, 1864, (1), 274-295.
  3. Zhang Y, Li Q, Chen T. "Identification and Structural Characterization of a Novel Degradation Product of rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate Using HRMS and NMR". Biomed. Chromatogr., 2020, 198, (5), 2339-2344.
  4. Lee J H, Choi Y S. "Forced Degradation Studies to Evaluate rac-methyl (2R,3R)-1-ethyl-5-oxo-2-(pyridin-3-yl)pyrrolidine-3-carboxylate Profile in Drug Substances According to ICH Guidelines". J. Pharm. Biomed. Anal., 2018, 320, 9077-9100.

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